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Two categories of mucosal lymphoid tissues:
- Inductive Sites
- Effector Sites
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What occurs at Inductive Sites?
Ag are encountered, processed and immune responses are initiated
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What occurs at Effector Sites?
Where Ab and CMI responses are carried out
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Example Inductive Sites (5):
- Tonsils
- Appendix
- GALT
- BALT
- Peyer's Pathes
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In the GI tract, what occurs at the Inductive and Effector Sites?
- Inductive= Ab Class switching in Peyer's Patches
- Effector= Ab secreted into lumen
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___ can be supplemented PO to a pregnant F
- IgA
- (Gi -> Mammary -> Colostrum)
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IgA act by ____ in the GI, while IgE and IgG carry out ____
- Immune Exclsuion
- Immune Elimination
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Immune Elimination-
- Ab destroys Ag within the surface tissues
- (IgE and IgG)
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How does IgA carry out immune exclusion in the GI tract?
It prevents adherence of bateria and viruses to epithelial surfaces
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Steps of IgA production (3):
- Secreted by plasma cell as a dimer, within the submucosa
- Binds to Poly-Ig Receptor, and trasported to luminal surface
- part of Poly-Ig is cleaved, but Secretory IgA remains (resistant to proteases)
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Uniquie ability of IgA
It can act intracellularly
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Immune Elimination is mediated by
IgE
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How does IgE carry out Immune Elimination?
It attaches to mast cells
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What tissues does IgE act on?
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When is IgE triggered?
When IgA is evaded and microorganism gains access to tissues
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How does IgA respond to intestinal parasite infection & what are the steps that follow?
IgA attaches to Mast Cell, causing it to degranulate
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Degranulation of Mast Cells ->
- (follows after IgA attaches)
- Inflammation
- Increased Vascular Permeability
- Fluid Leakage btw enterocytes
- Fluid into lumen ->
- Flush out parasites
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