Immuno E2, V

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Functions of Complement Proteins:
- Ab/Non-Ab lysis
- Opsonization for phagocytosis
- Inflammation
- Mast Cell Degranulation
- Clear immune complexes
Two pathways that activate the complement system
- Alternate/Natural Pathway
- Classical/Specific Pathway
The Alternate Pathway is also called...
- The lectin pathway
- (or Natural)
Which pathway is activated by the microbe alone?

Alternate
Which pathway is activated by Ab?

Classical
Which pathway is AKA the Lectin Pathway?

Alternate
What part of the Ab activates the Complement Protein C1?

Fc Region
Which classes of Ab trigger the Classical Pathway?
- IgG
- IgM (more efficient)
Which class of Ab is more efficient at triggering the Classical Pathway? Why?

IgM- Has closely spaced C' binding sites
The Classical Pathway reqires two Ig?

IgM
When does C1 bind to the Ab in the Classical pathway?

AFTER Ab binds to Ag
The ultimate task of the Complement Cascade is to form the ____, which leads to ____
- Membrane Attack Complex
- Cell Lysis
What are the end products of proteolysis and what happens to them?
- Small Protein- remains bound to complex at the surface of pathogen
- Peptide- diffuses away for other tasks (Mast Cell/Basophil degran and chemotaxis of neutrophils)
The complement system is effective in lysing (4):
- G- Bacteria
- Enveloped Viruses
- Parasites
- Fungi
How does Strep evade the Comp. System?

Capsule that prevents MAC insertion and C3b deposition
Bact can inactivate Comp. System via

Elastases
How do some viruses evade the Comp. System?

They possess protiens that mimic regulatory proteins
How do Tumor Cells evade the Comp. System?

They can endocytose MAC and seal up the membrane

Author

HLW

69066

Card Set

Immuno E2, V

Description

Immuno E2, V

Updated

2011-02-26T18:40:21Z

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