Immuno E2, III

Routes in which a B Cell is activated by an antigen:
- T-dependent
- T independent
What kind of antigens can evoke immunological memory and class switching?

Thymus-Dependent
Th1 cytokines induce what type of Ab?
- Cell mediated Ab
- (IgG & IgM)
Th2 cytokines induce what type of Ab?
- Neutralizing Ab
- (IgE, IgA and some IgG)
Ab produced by Thymus-Induces Ag's:
- IgM
- (very limited)
If a P lacks CD40L on Th cells, only ___ is produced

IgM
____ is preserved during class switching

Variable Region, or Ag specificity
Class switching is driven by:
- Cytokines (Th1 vs Th2)
- Repitition (2' immune sys)
Class switching allows Ab to change function (not specificity) by...

switching to a different class
Phases of Primary Ab response:
- lag
- Log
- Plateau
- Decline
What occurs during lag phase (3):
- Ag recognized by naive B cell
- B Cell proliferates & differentiates
- Makes Ab
Phases of 2' Ab response compared to 1' Ab response:
- Shorter Lag
- Rapid/Higher Log
- Long Decline (persists for months-life)
Major Ab class during 1'

IgM (doesn't persist)
Major Ab class during 2'

IgG, or IgA/IgE (DOES persist)
Ab responsible for blocking attachment of Ag

IgE
Ab responsible for Mast cell degranulation

IgE
Functions of Ab (6):
- Opsonization
- Neutralization
- Blocking of attachment
- mast Cell Degranulation
- ADCC (Ab dep cell cytotoxicity)
- Complement Activation
What do aggregations cause in vivo

Hypersensitivities or Immune Complex Dz
What can aggregations be used for in vitro?

Dx

Author

HLW

68988

Card Set

Immuno E2, III

Description

Immuno E2, III

Updated

2011-02-26T03:47:51Z

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