Immuno E2, III

  1. Routes in which a B Cell is activated by an antigen:
    • T-dependent
    • T independent
  2. What kind of antigens can evoke immunological memory and class switching?
  3. Th1 cytokines induce what type of Ab?
    • Cell mediated Ab
    • (IgG & IgM)
  4. Th2 cytokines induce what type of Ab?
    • Neutralizing Ab
    • (IgE, IgA and some IgG)
  5. Ab produced by Thymus-Induces Ag's:
    • IgM
    • (very limited)
  6. If a P lacks CD40L on Th cells, only ___ is produced
  7. ____ is preserved during class switching
    Variable Region, or Ag specificity
  8. Class switching is driven by:
    • Cytokines (Th1 vs Th2)
    • Repitition (2' immune sys)
  9. Class switching allows Ab to change function (not specificity) by...
    switching to a different class
  10. Phases of Primary Ab response:
    • lag
    • Log
    • Plateau
    • Decline
  11. What occurs during lag phase (3):
    • Ag recognized by naive B cell
    • B Cell proliferates & differentiates
    • Makes Ab
  12. Phases of 2' Ab response compared to 1' Ab response:
    • Shorter Lag
    • Rapid/Higher Log
    • Long Decline (persists for months-life)
  13. Major Ab class during 1'
    IgM (doesn't persist)
  14. Major Ab class during 2'
    IgG, or IgA/IgE (DOES persist)
  15. Ab responsible for blocking attachment of Ag
  16. Ab responsible for Mast cell degranulation
  17. Functions of Ab (6):
    • Opsonization
    • Neutralization
    • Blocking of attachment
    • mast Cell Degranulation
    • ADCC (Ab dep cell cytotoxicity)
    • Complement Activation
  18. What do aggregations cause in vivo
    Hypersensitivities or Immune Complex Dz
  19. What can aggregations be used for in vitro?
Card Set
Immuno E2, III
Immuno E2, III