Immuno E2, II
[IgG] is highest in the ____
blood (but not always highest [Ig])
Main Ab of secondary responses
Functions of IgG (6):
Bind pathogens and
Binds and neutralizes toxins
Binds and opsonizes phagocytes (via Fc)
Complement Activationa nd destruction of microbe
Ab-dependent cell cytotoxicity
Which Ab is found in colostrum?
Which Ig is made first as specific response develops?
Functions of IgM (3):
Opsonization through complement
A high concentration of which class indicates exposure to an Ag?
Why can't IgM perform Ag-Dep-cytotoxicity?
No Fc receptor on phagocytes for IgM
How does IgM overcome inability to opsonize?
by binding to complement
(1,000 X more potent than IgG)
How does the size of IgM affect it's functions?
Too large to penetrate tissues so it remains in the blood and lymph
Which class of Ab is passed through milk?
Structure of IgA in serum and in mucosal surfaces
What is the purpose of a dimeric IgA?
It has a secretory piece that prevents it from being degraded by proteases in the intestine
Which class => mucosal protection?
How does IgA provide mucosal protection?
Prevent Ag from adhering to epithelium
Functions of IgE:
Immunity to parasitic worms
IgE binds to
How long the half of IgE when in free solution, and when bound to a cell?
Solution= 2-3 days
Bound= 11-12 days
What Ab class is responsible for Type II Sensitivity?
Immuno E2, II
Immuno, E2, II