Immuno E2, II

  1. [IgG] is highest in the ____
    blood (but not always highest [Ig])
  2. Main Ab of secondary responses
  3. Functions of IgG (6):
    • Bind pathogens and
    • Binds and neutralizes toxins
    • Binds and opsonizes phagocytes (via Fc)
    • Complement Activationa nd destruction of microbe
  4. Ab-dependent cell cytotoxicity
  5. Which Ab is found in colostrum?
  6. Which Ig is made first as specific response develops?
  7. Functions of IgM (3):
    • Neutraliztion
    • Aggregation
    • Opsonization through complement
  8. A high concentration of which class indicates exposure to an Ag?
  9. Why can't IgM perform Ag-Dep-cytotoxicity?
    No Fc receptor on phagocytes for IgM
  10. How does IgM overcome inability to opsonize?
    • by binding to complement
    • (1,000 X more potent than IgG)
  11. How does the size of IgM affect it's functions?
    Too large to penetrate tissues so it remains in the blood and lymph
  12. Which class of Ab is passed through milk?
  13. Structure of IgA in serum and in mucosal surfaces
    • Serum= monomeric
    • Mucosa= Dimer
  14. What is the purpose of a dimeric IgA?
    It has a secretory piece that prevents it from being degraded by proteases in the intestine
  15. Which class => mucosal protection?
  16. How does IgA provide mucosal protection?
    Prevent Ag from adhering to epithelium
  17. Functions of IgE:
    • Immunity to parasitic worms
    • Histamine release/Inflammation
  18. IgE binds to
    • Mast cells
    • Basophils
    • Eosinophils
  19. How long the half of IgE when in free solution, and when bound to a cell?
    • Solution= 2-3 days
    • Bound= 11-12 days
  20. What Ab class is responsible for Type II Sensitivity?
Card Set
Immuno E2, II
Immuno, E2, II