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What are the 3 aspects of addiction?
- Biological: genetics, low MAO, dehydrogenase, dopamine, acetate
- Social: stigma, environment, peers, family, abuse
- Psychological components: STRESS, depression, low self esteem, need for power, coping, hyperactivity, antisocial
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What is the brain reward system?
- Deals with the limbic system
- Dopamine and pleasure circuit
- Drugs change brain physically and mentally
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How does the adolescent brain mature?
- Back: areas of emotion, memory, impulse, psychomotor activity
- Front: areas of fxn, planning, problem-solving, judgement, impulse control, organization (rational decision making)
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What happens to pathways when addicted?
Pathways change & not always recovered
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What disorders can drug use cause?
- Aggressiveness
- Isolation
- Depression
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Discuss addiction and brain circuits
- Addiction changes brain circuits
- Which leads to control circuit being impaired
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Define Addiction
Uncontrollable, compulsive drug seeking & use, even in the face of negative health & social consequences
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Discuss Addiction
- Chronic relapsing disorder/ disease
- Erodes self control and ability to make decisions
- No longer "free choice"
- Intense impulses to seek and take drugs
- Characterized by neuro-chemical and molecular changes in brain
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What Environmental Influences lead to drug use?
- Early physical or sexual abuse
- Witnessing violence
- Stress
- Peers who use drugs
- Drug avaliability
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Define Craving
- Intense wanting
- The more you want the drug, the less you like it
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Discuss craving r/t physiology
- Just 1 drink makes you want more
- Acetate accumulates, causing the want more more acetate
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Where does craving occur?
- Amygdala
- Part of the limbic system that controls memory and emotions
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What are reasons for continued drug abuse?
- Genetics, experience, environment, & drug effects create positive responses
- Changes in neurotransmitters lead to tolerance and withdrawl syndromes
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Differentiate between use, abuse, & dependence
- Abuse is using beyond the intended use
- Dependence is physiological dependence with tolerance and withdrawl
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Define Physical Dependence/ tolerance
- Not the same as addiction
- An adaptive physiological state that results in withdrawl
- Not drug seeking
- Body requires more of substance to sustain the effect- body has gotten used to medication
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Define Substance Abuse
- Maladaptive pattern of use leading to clinical significant impairment or distress manifested by one of the following within a 12 mo period:
- Recurrent use with a failure to fulfill a major role at work, school, or home
- Recurrent use in situations where use is physically hazardous
- Recurrent substance-related legal problems
- Recurrent use despite persistent social or interpersonal problems caused or exacerbated by substance use
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Defined Substance Dependence
- At least 3 characteristics over 12 mos:
- Evidence of tolerance
- Evidence of withdrawl
- Substance taken in larger amt or over long period of timd than intended
- Persistent or unsuccessful desire to cut down or control use
- Great deal of time spent in obtaining, using or recovering from substances
- Cont'd use despite knowledge of persistent psychological or physical problems
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Differentiate Dependence vs Abuse
- Dependence includes tolerance, withdrawl, or a pattern of compulsive use
- Abuse includes only harmful consequences of repeated use
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Define Substance Induced Mood Disorder
- A mood disturbance is prominent and persistent and is characterized by either (or both) of the following:
- Depressed mood and markedly diminished interest or pleasure in all, or almost all, activities
- Elevated, expansive, or irritable mood
- Rule out: Axis 1 mood d/o or delerium
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Discuss Sx dev, Sx SE, and Meds of Substance Induced Mood Disorder
- Sx developed during, or within a month of Substance Intoxication or Withdrawal
- Sx cause clinically significant distress or impairment in social, occupational, or other important areas of functioning
- Med use is etiologically r/t the disturbance
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List Parts of Substance Use Assessment
- Blood ETOH level (BAC)- 1oz/hr healthy liver metabolized
- Drugs of Abuse Screen
- Blackouts- still can fxn, but doesn't remember/aware
- Withdrawal
- Intoxication
- Delirium Tremens
- Relapse- recurrance of drug or ETOH abuse for significant amt of time
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Discuss Blackouts from Book
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Discuss Physiological Effect of Opioids
- Opioids bind special proteins causing a block in transmission of pain messages to the brain
- Opioids SE- drowsiness, constipation, respiratory depression
- Cause Euphoria- pleasure in the brain
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List ACUTE Physiological Effects of ETOH
- CNS Depressant
- sedation
- confusion
- impaired motor fxn or speech
- coma
- respiratory failure
- death
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List LONG-TERM Physiological Effects of ETOH
- cerebellar degeneration
- impaired coordination
- broad-based unsteady gait
- fine tremors
- Dependence
- Cirrhosis
- ETOH-induced amnestic d/o
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List ACUTE Effects of Methamphetamines
- Speeds up brain, nervous system, and body
- Inc RR, BP, Temp
- More alert/awake
- Restlessness
- Insomnia
- Dec appetite
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List LONG-TERM Effects of Methamphetamines
- Brain/heart damage
- Labile mood
- Violent/ aggressive behavior
- Hallucinations
- Paranoia
- Wt loss
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List ACUTE Effects of Cocaine
- Speeds up body and brain
- Inc RR, BP, Temp
- More alert/awake
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List LONG-TERM Effects of Cocaine
- Lung damage
- Nasal ulcers
- Personality changed
- Violent/ aggressive bahavior
- Paranoia
- Hallucinations
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List Sx of Sedative-Hypnotic Withdrawal Guide
- Diaphoresis
- Hallucinations
- Confusion
- Tremor
- Restlessness
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List Assessment Pearls reguarding Sedative-Hypnotic Withdrawal Guide
- Check neck for diaphoresis
- Observe pt for hallucinations
- Check abdomen for tremors
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Discuss Withdrawal Pt Education Handout
- Prevent falls due to Orthostatic Hypotension
- Get up slowly
- Sit on edge of bed for 1 min
- Drink 8-10 glasses of water
- Report Dizziness
- Do NOT flush vomit or diarrhea
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List Sx of Opioid Withdrawl Tool
- Dialated pupils
- Gooseflesh
- Muscle Twitching
- BP
- Pulse
- Temp
- Vomitting
- Diarrhea
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List Assessment Pearls reguarding Opioid Withdrawal Tool
- Run fingers over forearm for gooseflesh
- Sit for 5 min before BP
- Tell pt- save vomit
- Warm shower for aches
- Non-med interventions
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Discuss Intoxication
- Obvious impaired judgement and functioning, & maladaptive behavior
- Scales: arousal, speech, gait, romberg, nystagmus
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Discuss Dual Diagnosis
- Co-existing substance d/o and mental d/o may be assigned to special program
- Program combines special therapies that target both problems
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Discuss Detoxification
- Safe removal of the chemical from the body
- Provide for physical, emotional, and psychological safety
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List Meds for ETOH detox/ Immediate Tx
- Benzos
- Anticonvulsants
- Multivitamin Therapy
- Thiamine
- (note: tremors preceed seizures)
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List ETOH Delirium Tremens: DTs: Sx
- Occur w/in 24-48 hrs, and continue 1 week
- Agitation, confusion, anxiety, delusions, coarse tremors, fever, diaphoresis, inc heart rate, precordial pain
- Seizures
- Hallucinations- tactile & auditory
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List Delirium Tremens: Dts: Treatment
- Life-support
- Labs (electrolytes)
- Hydrate
- VS
- Tx seizures
- Tx BP w/ Clonidine
- Tx w/ haldol
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List Tx for Opioid Detox/ Immediate Tx
- Narcan (if resp distress)
- ReVia or Revex (long term antagonists)
- Methadone or Bupreorphine (slow replacement)
- Clonidine (emergency BP)
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Discuss Methadone Maintenance in Prego
- Steady State for baby
- Baby 2-3X more intense
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List Nsg Intervention for Methadone Addicted Prego with W/D Sx
- Holistic Care (esp. non-med interventions)
- Referrals to programs
- Care and nurture
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List Nsg Dx
- Ineff denial
- Early: Imbalanced Nutrition
- After: Ineffective Coping
- Not urgent: Risk for infection, low self-esteem, knowledge deficit
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List Outpatient Tx (Meds) for ETOH and Opioids
- ETOH: Disulfiram, Naltrexone, Campral
- Opioids: Burenorphine
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List Brief Intervention: The Frames Model
- Feedback- drinking is risky
- Responsibility- client change behavior
- Advice to change
- Menu of ways to reduce drinking
- Empathic counseling
- Self-efficacy (give message of empowerment)
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Discuss Nsg Interventions and Tx Modalities
- Reduce
- Harm reduction
- Consequences (job)
- Follow-up
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Discuss Rehab/ Recovery
- Encourage cont'd participation in long-term tx
- Promote participation in outpt support system
- Assist client to id alternative sources of satisfaction
- Provide support for health promotion and maintenance
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List HCP Priorities
- Provide support
- Strengthen coping skills
- Facilitate learning
- Promote family involvement
- Facilitate family growth/dev
- Provide info
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List HCP Common D/C Goals
- Responsibility for own life
- Plan for substance-free
- Family relationships addressed
- Tx program started
- Condition, prognosis, therapy understood
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Discuss Mgt of Illness (Teaching)
- Activities to substitute substances in times of stress
- Relaxation techniques
- Problem-solving skills
- Essentials of good nutrition
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Discuss Naltrexone for Tx ETOH Dependence
- Blocks receptors resulting in Reduced Craving
- Contraindicated in acute opioid withdrawal
- Precipitates severe withdrawal if depended on opioids
- Monitor liver fxn
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Discuss Acamprosate (Campral) for Tx ETOH Dependence
- Action: Affects glutamate neurotrasmitter
- Monitor renal fxn
- Adverse: SI and behavior
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Discuss Disulfiram for Tx ETOH Dependence
- Action: inhibits metabolism
- DO NOT DRINK ETOH w/in 12 hrs!!!
- Rxn- flushing, sweating, nausea, tachycardia
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