Lecture 28: Female Reproductive System II

  1. Layers of uterus
    • 1. Perimetrium
    • 2. Myometrium- thick m layer, basket-weave, no pattern; mild contraction- mentrual pain; strong contraction to expel baby
    • 3. Endometrium-
    • tubular glands
    • 2 layers: Basal layer, FUnctional layer- repsonsive to steroids, no preg=layer sloughed off, spiral arteries
  2. Menstrual phase
    • 1-4 days
    • Hormones low
  3. Early proliferative phase
    • 4-7
    • wounded surface repaired
    • regenerate basal zone
    • endometrium is thin
    • glands short, straight
  4. Late proliferative phase
    • 7-14
    • epithelium now tall, crowded
    • Peak estrogen secreted by ovary
    • tremendous growth of everything
    • endometrium tall
    • fuctional layer large
    • glands coiled
  5. Early secretory phase
    • 15-21
    • after ovulation
    • Progesterone increases RAPIDLY!
    • glands large, highly coiled
    • glycogen below nucleus
    • at end of phase above
    • at end of phase, implantation
    • less dense stroma b/c mitosis slows
  6. Late secretory phase
    • 21-28
    • at beginning of phase- Prgesterone HIGH
    • glands exteremely torturous "back to back" appearance
    • apocrine secretion-> "ruffled" cells
    • Decidual reaction- occurs whether or not preg, around spiral arteries; spreads if preg
    • If preg- prgesterone levels maintained.
    • No preg- P levels drop, endometrium collapsed, inc leukocytes, spriral ateries kink->ischemia, tissue damage, leaking of blood, menstrual bleeding begins again
  7. Cervix
    • Endocervix: SIMPLE COLUMNAR, secretes cervial mucus: viscous plus, estrogen changes propertied near ovulation so sperm can penetrate
    • External os: transition of epithelium, metaplasia
    • Ectocervix: STRATIFIED SQUAMOUS (like vagina)
  8. Vagina
    • non-keratinizing stratified squamous (like in endocervix)
    • Layers: mucosa, muscularis (IC,OL-> like ampulla), adventitia (NOT serosa as seen in FT)
    • Epithelial cell layers: basal layer, prickle cell layer: has Langerhans (sim to skin), Glycogen-containing cells: lower plump vaculated, topmost squamous vaculated
  9. Breast
    • Alveoli- milk fat globules, proteins- meocrine
    • Supporting cells: LCT, mast cells, plasma cells: produce IgA Ab's cross epitelial cells
    • Duct: small ducts- CUBOIDAL; large duct: COLUMNAR. Largest= lactiferous duct- STRATIFIED COLUMNAR which exits each lobe, form sinus, empties to surface
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Lecture 28: Female Reproductive System II
Female Reproductive System II