Most common adult primary brain tumor. Grave prognosis (<1 year life expectancy) Found in both hemispheres because it can cross the corpus callosum (like a butterfly-butterfly glioma). Stains positive for GFAP (astrocyte marker)
Second most common adult primary brain tumor. Often occurs in convexities of hemispheres and parasagittal region. Arises from arachnoid cells external to brain. Resectable.
Third most common adult primary brain tumor. Schwann cell origin-often localized to CN VIII. Resectable
Schwannoma (acoustic schwannoma)
Relatively rare, slow growing brain tumore. Most often in frontal lobes. Chicken wire capillary pattern
Most commonly prolactinoma. Bitemporal hemianopia (due to pressure on optic chiasm) and hyper/hypo-pituitarism are sequelae.
Usually well-circumscribed. In children most often found int the posterior fossa. May be supratentorial. GFAP positive. Benign, good prognosis
Pilocytic (low-grade) astrocytoma
Highly malignant cerebellar tumor more common in children. A from of primative neuroectodermal tumor (PNET). Can compress 4th ventricle, causing hydrocephalus.
Ependymal cell tumors most commonly found in the 4th ventricle; can cause hydrocephalus. Poor prognosis. More common in children
Most often cerebellar and in kiddos; associated with von Hippel-Lindau syndrom when found with retinal angiomas. Can produce EPO causing polycythemia
Benign childhood tumor confused with pititary adenoma (can cause bilat hemianopia). Most common childhood supratentorial tumor.
Pseudopalisading pleomorphic tumor cells--border central areas of necrosis and hemorrhage
spindle cells concentrically arranged in a whorled pattern; psammoma bodies (laminated calcifications)
Bilat tumor found in neurofibromatosis type 2
"fried egg" cells-round nuclei with clear cytoplasm (halos) often calcified
Derived from Rathke's pouch
Rosenthal fibers--eosinophilic, corkscrew fibers
Rosettes or perivascular pseudorosette pattern of cells. Radiosensitive
Chracteristic perivascualr pseudorosettes. Rod-shaped blepharoplasts (basal ciliary bodies) found near nucleus.
foamy cells and high vascularity are characteristic
derived from remnants of rathke's pouch. Calcification is common (tooth enamel-like)