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Block 3 Lipids
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FA are amphipathic, what does it mean?
They have hydrophilic and hydrophobic parts
How many carbons is palmitoyl acid?
16
How many carbons is stearic acid?
18
How many carbons is arachidonic acid?
20
What are the 3 ketone bodies?
Acetone
Acetoacetate
3- hydroxybutarate
Linolenic acid is how many carbons?
18
What are the essential FA?
Linoleic
Linolenic
What is the rate determining enzyme for FA degradation?
Carnitine acyltransferase I
What is the rate determining enzyme for FA synthesis?
Acetyl CoA carboxylase
Needs Biotin
FA synthesis occurs where?
Cytosol
FA degradation occurs where?
Mitochondria
Synthetic intermediates are carried by what?
acyl carrier protein(ACP)
Degradation products are carried by what?
Coenzyme A
Allosteric Inhibition of what enzyme allows citrate to diffuse out of the mitochondria?
Isocitrate dehydrogenase
What enzyme converts citrate to acetyl coa on the cytosolic side?
ATP-dependent Citrate Lyase
What activates acetyl coA carboxylase?
citrate
What deactivates acetyl CoA carboxylase?
LCFA-CoA
What effect does glucagon have on acetyl coA carboxylase?
Deactivates it by phosphorylating it
What effect does high carbohydrate diet have on ACC?
High carbohydrate diet upregulates the expression of ACC
What effect does insulin have on ACC?
It dephosphorylates it by activating phosphotases
In the cytosol, ACC converts acetyl coA into?
malonyl coA
What gene is sometimes upregulated in breast cancers that has to do with fatty acid synthesis?
FAS--fatty acid synthase
Paroxysmal Nocturnal Hemoglobinuria
PICA gene mutation
What FA is needed for prostoglandin synthesis?
Arachidonic acid
Sphingomyelinase deficiency results in what?
Nieman-Pick Disease
Glycosphingolipid unlike sphingomyelin does not contain what?
Phosphate
Types of Glycosphingolipids?
cerebrosides
globosides
gangliosides
Cerebrosides are what type of monosaccharides?
Ceramide
Example of an acidic glycerophospholipid?
Ganglioside
Surfactant A is a what type of complex lipid?
Lecitin
Author
pszurnicki
ID
67363
Card Set
Block 3 Lipids
Description
Block 3 Lipids
Updated
2011-02-21T22:12:40Z
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