Cartilage S1M2

  1. All three types of cartilage have at least a little of what coll type
    Type II
  2. What are the functions of cartilage
    • Support soft tissues
    • Resist Compression
    • Provide sliding surface for joints
    • Act as a template for long bone growth
  3. What makes the cartilage have a hard consistancy
    Proteoglycans and collagen
  4. What three important components do cartilage lack
    • Vessels
    • Nerves
    • Lymph
  5. The hard consistancy of cartilage can be attributed to
    • Coll. Typ II
    • Proteoglycans
  6. Without vessels, how does cartilage obtain nutrients
    Through diffusion
  7. What cartilage types do not contain perichondrium
    • Articular cartilage
    • Fibrocartilage
  8. Perichondrium is made up of
    Dense connective tissue, Coll. type I, fibroblast cells
  9. What is articular cartilage
    It is found on top of bones and is a subclass of hyaline cartilage, it contains no perichondrium
  10. Type IV coll. is found only in
    Basal Lamina
  11. What are the three different types of cartilage
    • Hyaline cartilage (most abundant)
    • Elastic cartilage
    • Fibrocartilage
  12. Hyaline cartilage has what coll. in its matrix
    Coll type II
  13. Elastic Cartilage has lots of elastic fibers and what in its matrix
    Hyaline cartilage
  14. Bone is made of what collagen type
  15. Fibrocartilage has what abundant coll type
    I, and the matrix is made of hyaline cartilage
  16. Hyaline matrix is made up of
    • Coll. Type II
    • Proteoglycans
    • Adhesive gylcoproteins
  17. Why can't you see Coll. type II
    The refractive index is the same as ground substance
  18. The matrix in hyaline cartilage is produced by
  19. Proteoglycans contain what three GAG's
    • Chondroitin 4 Sulfate
    • Chondroitin 6 Sulfate
    • Karatan Sulfate
  20. What forms large Proteoglycan Aggregates
    Chondroitin 4 Sulfate, Chondroitin 6 Sulfate, Keratan Sulfate linked to hyaluronic acid
  21. A papain injection has what effect
    It is an enzyme that breaks down protein molecules and destroys proteoglycans (Which causes them to no longer attract water)
  22. Adhesive glycoproteins has binding sites for
    • Coll. II
    • GAG's
    • Hyaluronic acid
    • Integrins of chondrocytes
  23. How are hyaluronic acid aggregates bound to collagen
    Electrostatic interactions and glycoproteins
  24. What is the most abundant adhesvie glycoprotein in cartilage
  25. Chondronectin is
    A cartilage matrix protein that specifically mediates the attachment of chondrocytes to type II collagen
  26. Why is ground substance stained with basic dyes
    Because it has a negative charge due to the large amounts of GAG's
  27. A cluster of Chondrocytes is called
    An isogenous group
  28. Chondrocytes have a lot of RER and Golgi, this would indicate
    That they make a lot of proteins
  29. Chondrocytes make what
    • Coll II
    • GAG's
    • Proteoglycans
    • Adhesive glycoproteins
  30. Chondrocytes sit in
  31. What are the triggers for the synthesis of sulfated GAG's by chondrocytes
    • GH
    • Somatotropin
    • Thyroxine
    • Testosterone
  32. Chondrocytes decrease the synthesis of sulfated GAG's by responding to
    • Cortisol
    • Cortisone
    • Estradiol (found in ovary)
  33. Cartilage growth depends primarily on what hormone
    GH which triggers the liver to release somatomedin C
  34. Cartilage grows by what two means
    • Appositional Growth (Outside in)
    • Interstitial Growth (Inside out)
  35. Interstitial growth happens primarily when and where
    • In early development
    • articular cartilage
    • Epiphyseal plates of long bones
  36. Elastic cartilage is identical to hyaline cartilage except
    Its matrix and perichondrium also contain elastic fibers
  37. What are some places elastic cartilage can be found
    • Pinna of ear
    • External and internal auditory tubes
    • Epiglottis
    • Laryx
  38. Fibrcartilage has no
  39. Fibrocartilage is a combination of
    Dense regular connective tissue and hyaline cartilage and is predominantly Coll. I
  40. Collagen type one stains
  41. Fibrocartilage can be found in what locations
    • Intervertebral discs
    • Symphysis pubis
    • Menisci of the knee
    • Any area that requires support and tensile strength
  42. Annulus fibrosus is made up primarily of
    Coll. I
  43. Nucleus pulposes is made of primarily
    Coll. II and hyaluronic acid
  44. Articular cartilage grows only how
    Interstitial growth
  45. Interterritorial matrix is rich in what
    Coll II (low a proteoglycans)
Card Set
Cartilage S1M2
Micro Anatomy