1. drugs are one of the tools used in the treatment of malignant diseases
  2. therapy used with antineoplastics?
  3. spreading of the cancer to other sites?
  4. comfort care, the relief of symptoms at the end of life?
  5. list the 5 phases of cell growth?
    • G1-RNA and proteins are built
    • s- DNA is made from the components of G1.
    • G2- mitotic cell division (doubled and split in 2 divisions)
    • G0- the dormant resting phase
  6. this targets the cell in one of the phases of cell division
  7. they can target the cell at any phase of the cycle?
  8. localized tumor that has fibrous capsule, limited growth, reg shape, well differentiated. does not invade other tissue or have mets
    benign neoplasm
  9. grows, invades and has mets. irregular shape and composed of poor differentiated cells, can result in death
    malignant neoplasm
  10. this type of cell has no enclosing capsule?
    malignant cell
  11. this is a tumor that develops away from the sit or orgin?
  12. when is chemo given to optimize cell death?
    when the cells are splitting
  13. what percentage of cells are killed during the first round of chemo?
  14. during the second round of chemo what percentage is killed?
    another 90% of the remaining
  15. this therapy is designed to relieve or reduce intensity of uncomfortable symptoms
    pallitive therapy
  16. to reduce the bulk of the tumor, control bleeding and remove blockage
  17. reduce tumor size, limits mets, allieve pain, bleeding and obstruction
  18. reduce tumor size and limit mets
  19. chemo can lead to what physical developments?
    thrush, stomatitis
  20. how is chemo administered?
    systemically and affects normal and irregular cells
  21. CCS are common to treat what type of cancers?
    luekemia, lymphomas and solid tumors
  22. drugs derived from vinca, alkaloids, taxanes, podophyllotoxins and camptothenin analog drugs?
    plant alkaloids- CCS drugs
  23. drug or other substance that is an antagonist or that resembles a normal human metabolite and interes with its function in the body
    antimetabolite drugs - CCS
  24. usually competes with the metabolites receptors or enzymes, interferes with the synthesis of RNA and DNA which makes it impossible for the cells to divide
    CCS antimetabolite drugs
  25. example of antimetabolite drugs?
    methotrexate/ folic acid
  26. this drug is does dependent?
  27. used to cure,control, and provide palliation in the treatment of leukemias, lymphoma and diff solid tumors and certain autoimmune disease
  28. examples of alkalating agents?
    vincristine and vinbrlastine from periwinkle plant
  29. agents that bond with DNA molecules and prevent cell division. will bond with DNA during any mitosis stage
  30. interferes with DNA and RNA synthesis, delaying or inhibiting cell dividing and blocking the reproductive ability
    antineoplastic antibiotics
  31. examples of antineoplastic antibiotics?
    adriamycin, used in treatment of solid tumors
  32. substance that acts to alter the immune response by augumenting the bodys defense mechanisms or changing the way the body respons to cancer?
  33. adverse reactions of antineoplastics?
    the immediate would be n/v
  34. a prevention to help n/v ?
    giving a antiemetic before an antineoplastic
  35. other adverse reactions of antineoplastics?
    bone marrow suppression, anemia, leukopenia, thrombocytopenia, stomatitis, diarrhea, hair loss
  36. some adverse reactions of alkaloids?
    peripheral tingling sensation to hand and feet, tiny capillary leaks, skin color changes
  37. help reduce the toxicity of chemotherapeutic agents to normal cells
    chemoprotective agents
  38. estrogen, a hormonal agent is used to treat what tumor that is hormone dependent?
    post menopausal breast cancer
  39. what do androgen hormonal agents treat?
    metastatic breast cancer of any age
  40. estrogen can also treat what kind of tumor in men?
  41. this hormonal agent is used to treat lymphomas and leukemias
  42. antineoplastic drugs are contraindicated in pt with?
    leukopenia, thrombocytopenia, anemia, serious infections, serious renal disease, HTN, during pregnancy or lactation
  43. these drugs are used with antineoplastics to protect normal cells or organs of the body?
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