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drugs are one of the tools used in the treatment of malignant diseases
antineoplastic
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therapy used with antineoplastics?
chemo
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spreading of the cancer to other sites?
metastasis
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comfort care, the relief of symptoms at the end of life?
palliation
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list the 5 phases of cell growth?
- G1-RNA and proteins are built
- s- DNA is made from the components of G1.
- G2- mitotic cell division (doubled and split in 2 divisions)
- G0- the dormant resting phase
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this targets the cell in one of the phases of cell division
CCS
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they can target the cell at any phase of the cycle?
CCNS
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localized tumor that has fibrous capsule, limited growth, reg shape, well differentiated. does not invade other tissue or have mets
benign neoplasm
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grows, invades and has mets. irregular shape and composed of poor differentiated cells, can result in death
malignant neoplasm
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this type of cell has no enclosing capsule?
malignant cell
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this is a tumor that develops away from the sit or orgin?
metastasis
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when is chemo given to optimize cell death?
when the cells are splitting
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what percentage of cells are killed during the first round of chemo?
90%
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during the second round of chemo what percentage is killed?
another 90% of the remaining
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this therapy is designed to relieve or reduce intensity of uncomfortable symptoms
pallitive therapy
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to reduce the bulk of the tumor, control bleeding and remove blockage
surgery
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reduce tumor size, limits mets, allieve pain, bleeding and obstruction
radiation
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reduce tumor size and limit mets
chemo
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chemo can lead to what physical developments?
thrush, stomatitis
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how is chemo administered?
systemically and affects normal and irregular cells
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CCS are common to treat what type of cancers?
luekemia, lymphomas and solid tumors
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drugs derived from vinca, alkaloids, taxanes, podophyllotoxins and camptothenin analog drugs?
plant alkaloids- CCS drugs
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drug or other substance that is an antagonist or that resembles a normal human metabolite and interes with its function in the body
antimetabolite drugs - CCS
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usually competes with the metabolites receptors or enzymes, interferes with the synthesis of RNA and DNA which makes it impossible for the cells to divide
CCS antimetabolite drugs
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example of antimetabolite drugs?
methotrexate/ folic acid
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this drug is does dependent?
CCNS
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used to cure,control, and provide palliation in the treatment of leukemias, lymphoma and diff solid tumors and certain autoimmune disease
CCNS
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examples of alkalating agents?
vincristine and vinbrlastine from periwinkle plant
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agents that bond with DNA molecules and prevent cell division. will bond with DNA during any mitosis stage
CCNS`
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interferes with DNA and RNA synthesis, delaying or inhibiting cell dividing and blocking the reproductive ability
antineoplastic antibiotics
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examples of antineoplastic antibiotics?
adriamycin, used in treatment of solid tumors
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substance that acts to alter the immune response by augumenting the bodys defense mechanisms or changing the way the body respons to cancer?
immunomodulators
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adverse reactions of antineoplastics?
the immediate would be n/v
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a prevention to help n/v ?
giving a antiemetic before an antineoplastic
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other adverse reactions of antineoplastics?
bone marrow suppression, anemia, leukopenia, thrombocytopenia, stomatitis, diarrhea, hair loss
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some adverse reactions of alkaloids?
peripheral tingling sensation to hand and feet, tiny capillary leaks, skin color changes
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help reduce the toxicity of chemotherapeutic agents to normal cells
chemoprotective agents
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estrogen, a hormonal agent is used to treat what tumor that is hormone dependent?
post menopausal breast cancer
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what do androgen hormonal agents treat?
metastatic breast cancer of any age
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estrogen can also treat what kind of tumor in men?
prostate
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this hormonal agent is used to treat lymphomas and leukemias
corticosteroids
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antineoplastic drugs are contraindicated in pt with?
leukopenia, thrombocytopenia, anemia, serious infections, serious renal disease, HTN, during pregnancy or lactation
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these drugs are used with antineoplastics to protect normal cells or organs of the body?
cytoprotective
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