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Human Physiology Cell Receptors
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What do phosphodiesterases do?
Metabolize cyclic nucleotides.
(i.e. - the breakdown cAMP as an example of negative feedback)
What are some examples of methylxanthines?
Caffeine, theophylline, and theobromide found in tea, coffee, and cocoa.
What do methylxanthines do?
Methylxanthines inhibit phosphodiesterases from metabolizing cAMP
List the 5 types of receptors
1) single transmembrane protein
2) enzyme-linked receptor
3) GABA receptor
4) G-protein coupled receptor
5) steroid receptor
What is a LIGAND?
It is a signal triggering molecule, binding to a site on a target protein.
(hormone neurotransmitter)
Does the receptor or the ligand determine cellular response?
The receptor
What is cAMP?
cyclic adenosine mono phosphate is a cyclic molecule made by adenylate cyclase
What does PKA do?
protein kinase A phosphorylates CREB when activated by cAMP
What does CREB do?
it binds to a specific DNA sequence call CRE when phosphorylated by PKA
_______=binds to=>receptor
hormone=binds to=>receptor
(*receptor is usually integral protein within cell membrane)
hormone=(_______)=>receptor
hormone=binds to=>receptor
(*receptor is usually integral protein within cell membrane)
hormone=binds to=>_____
hormone=binds to=>receptor
(*receptor is usually integral protein within cell membrane)
_______=activates=>G-protein
receptor=activates=>G-protein
receptor=(_______)=>G-protein
receptor=activates=>G-protein
receptor=activates=>_______
receptor=activates=>G-protein
________=releases=>alpha subunit
G-protein=releases=>alpha subunit
G-protein=(_______)=>alpha subunit
G-protein=releases=>alpha subunit
G-protein=releases=>____________
G-protein=releases=>alpha subunit
___________=binds to=>effector
alpha subunit=binds to=>effector
alpha subunit=(_______)=>effector
alpha subunit=binds to=>effector
alpha subunit=binds to=>______
alpha subunit=binds to=>effector
______=interacts with=>molecules
effector=interacts with=>molecules
(*effectors cause various cellular processes that depend on the effector*)
(examples of effectors - adenylate cyclase or phospholipase C)
effector=(______)=>molecules
effector=interacts with=>molecules
(*effectors cause various cellular processes that depend on the effector*)
(examples of effectors - adenylate cyclase or phospholipase C)
G-protein alpha subunits convert GTP to GDP (which inactivates it) when it binds to__________
the receptor protein/hormone complex
_____________=metabolizes=>cAMP
phosphodiesterase=metabolizes=>cAMP
phosphodiesterase=(_______)=>cAMP
phosphodiesterase=metabolizes=>cAMP
phosphodiesterase=metabolizes=>_____
phosphodiesterase=metabolizes=>cAMP
__________=inhibits=>phosphodiesterase
methylxanthine=inhibits=>phosphodiesterase
methylxanthine=(____)=>phosphodiesterase
methylxanthine=inhibits=>phosphodiesterase
methylxanthine=inhibits=>_________
methylxanthine=inhibits=>phosphodiesterase
Author
ffloyd
ID
67086
Card Set
Human Physiology Cell Receptors
Description
Human Phys flashcards for exam 1
Updated
2011-03-10T21:57:05Z
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