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Enzymes Bioenergetics
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What is a prosthetic group?
permanent coenzyme
Which enzymes show sigmoidal action curves?
Allosteric
Most enzymes show what kind of action curve?
Hyperbolic
A high Km suggest what?
Small affinity for substrate
i.e
glucokinase
What effect does a competitive inhibitor have on Km?
Makes it higher
i.e---lowers the affinity of the enzyme for the substrate
What effect does a competitive inhibitor have on Vmax and Km?
Vmax is the same and Km is increased
Enzyme capable of being competitively inhibited?
HMG-Coa reductase
inhibitor--crestor, lipitor, lovastatin
What effect does a noncompetitive inhibitor have on Vmax and Km?
decreases Vmax
unchanged Km
What effect does an uncompetitive inhibitor have on an enzyme?
Lowers Km
Lowers Vmax
What is a homotropic effector?
substrate is the effector
What is a heterotropic effector?
substance other than substrate has an effect on an enzyme
What are two enzymes indivative of myocardial infarction?
CK2
Lactate dehydrogenase
Type III collagen, Ehlers-Danlos Syndrom.. deficient enzyme?
Inheritance?
What would be deficient?
Lysyl Hydroxylase
AD
BV
Deamination of Cytosine to Uracil would be corrected by?
Base excision repair
Mismatch repair
Used when?
defective in what condtion?
Wrong bases are inserted
HNPC
Ciproflaxin inhibits what?
Topoisomerase II
Nitrous acid does what to bases?
deaminates them
Sigma subunit of RNA polymerase does what?
Sigma--Starts transcription by recognizing and binding to the promoter
Wobble hypothesis?
Inosine
In what a.a are cis bonds possible?
Proline
Drug similar to aminoacyl-tRNA?
Puromyocin
What are the sizes the the follwing vectors can carry?
P
P
C
B
Y
1-10
10-20
35-50
50-250
500-3000
What does a Genomic Library contain?
Exons and Introns
What does a cDNA library contain?
exons
Icterus?
Jaundice presents in the eye
Isochromosome results from what genetic phenomenon?
2 acrocentric chromosomes join end to end
An Isochromosome 21 carrier has what chance of having a child with a trisomy 21?
100%
What does not alter the allelic frequency in a population?
inbreeding
Uniparental Disomy?
Both chromosomes inherited from one parent
Male to male transmission?
Dyschondrosteosis
2 conditions that are x linked dominant?
RETT--lethal in males..otherwise..klinefelters
Vit D resistant rickets--hypophosphatemia
Author
pszurnicki
ID
66100
Card Set
Enzymes Bioenergetics
Description
Enzymes Bioenergetics
Updated
2011-02-14T02:08:38Z
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