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An undesired drug effect
Adverst Drug Effect (ADE)
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an allergic response that is not preceded by a prior exposure
anaphylactoid response
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immune responses associated with T lymphocytes
cellular immunity
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Cyclooxygenase inhibitors
COX-1, COX-2, COX-3
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a reaction that ivolves damage to tissue cells; can include overdose
cytotoxic reaction
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a substance (drug) of low molecular weight that cannot induce antibody formation unless attached to another molecule, usually a protein
hapten
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a situation in which a smaller than normal dose of a drug produces the intended effect
hyperreactive
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a unique or unexpected drug reaction, often related to genetic variations in the individual
idiosyncrasy
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specific signs of a given disease, and not associated with other conditions
pathognomonic
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defective development of the arms or legs, a teratogenic effect
phocomelia
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the state of body functions; sould be normal or abnormal
physiologic status
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a doseform that has no active ingredient; a "sugar pill"
placebo
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malignancy caused by a drug or chemical substance
primary oncogenic effect
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malignancy caused by immune suppresion, which allows oncogenic viruses to cause malignant changes in cells
secondary oncegenic effect
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infection caused by microbes that were not affected by anti-infective therapy, such as a yease infection following antibiotic therapy
superinfection
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the rapid development of tolerance to a drug
tachyphylaxis
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a substance capable of causing fetal deformity
teratogen
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a predictable ADE usually associated with the normal dose of a drug, but can include adverse effects of overdose
Type-A ADE
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An unpredictable ADE, not related to the dose
Type-B ADE
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ACE
angiotensin-converting enzyme
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