HISTOLOGY-Lecture 2-Tissues & Extracellular Matrix

group of cells that from similar strucural and functional associations

• composed of -
• Cells
• Extracellular matrix

• epithelial
• connective
• nervous
• muscle

• nonliving macromolecules
• manufactured by cells
• exported into extracellular space
• composed of ground substane & fibers

• Glycosaminoglycans - GAG
• Proteoglycans
• Adhesive Glycoproteins
• Fibronectin
• Laminin
• Entactin
• Tenascin
• Chrondronectin
• Ostronectin

Carboxyl groups

Sulfornated - all but one

Amino groups

Negative charge

• Polysaccharides
• -long rod-like chains
• -inflexible
• -unbranched
• -repeating disaccharides

• long rod-like chains
• inflexible
• unbranched
• repeating disaccharides

attracts Na+

Na+ attracts water

water resists compression

will form covalent bonds with proteins

keratin sulfate

heparin sulfate

heparin

chondroitin-4-sulfate

chondroitin-6-sulfate

cermatan sulfate

hayaluronic acid - nonsulfated