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life span on neutrophils
short
4 Major parameters/cells types of the innate immune:
inflammation
phagocytic cells
NK cells
Soluble defense factors
Functions of TLR
Microbial recognition, engulfing & Killing
Mediate innate (inflammation)
Mediate Acquired (Humoral and CMI)
Antigenicity-
Abitility of Ag to bind to immune components
Immunogenicity-
The ability of an Ag to illicit an immune response
Epitope-
immunogenic part that binds to Ab or TLR
APC's (3):
Dendritic Cells
Macrophages
B-Cells
Professional APC=
Dendritic Cells
Semi-Pro APC=
Macrophages
B-Cells
After Ag is captured, immature dendritic cells migrate to...
Secondary Lymph tissues (ie LN)
After AG is captured, MATURE dendritic cells migrate to...
Secondary Lymph Tissue
Endogenous Ag presents via...
MHC I
Exogenous Ag presents via...
MHC II
Exogenous APCs can also present endogenous Ag if via MHC I...
Intracellularly infected
MHC I: _____ Ag Processing to _____
Endogenous
Cytotoxic T
MHC II: ____ Ag processing to _____
Exogenous
T-Helper
CD-4=
Cytotoxic
CD-8+
Helper
MHC II is expressed only by...
Phagocytic APCs
MHC I is expressed by...
All Nucleated Cells
MHC I is active when...
infected
Specificity/Diversity of BCR's and TCRs is made possible by...
Somatic Gene Rearrangement
B & T cells mature within the ___ Lymph Tissue
Primary
Upon leaving the thymus, T-Cells are mature, but...
Naieve until presented by MHC-Ag complex
Effector B-Lymphocytes:
Plasma Cells
Effector T-Lymphocytes:
Th that aids other T & B cells
Tc that kill infected cells and tumor cells
Tc Ag processing and differentiation occurs in the ____ Lymph Tiss
Secondary
The Tc receptor is located...
membrane bound
Ways in which a is T-cell activated:
Direct (TcR + MHC + Ag)
Costimulation (TcR + MHC + Ag + costim molecules)
Tc is activated by..
MHC II Ag presentation
Th1 cytokines:
IL-2
IN-y
TNF
IL-2->
Activation of TCells, BCells & NK
IN-y ->
Activation of MO
TNF ->
Marks tumor cells
Th2 Cytokines
IL-4
IL-5
IL-6
IL-10
Functions of Th2 cytokines:
Stimulate B-call proliferation
Neutralizing Ab secretion
Resistance to extracellular pathogens
Th2 killss:
Infected cells (w/ endogenous Ag)
Transformed cells (tumor Ag)
MHC Incompatible cells (non-self)
B-Cells mature when...
they react with Ag
B-Cell receptor is located..
in the membrane
B-Cells are activated when
Ag binds to BCR
Th cell signal
NK cells have receptors for:
Fc part of Ab
Complement Proteins
NK Cells are regulated by:
Cytokines
NK Cells target cells that...
Dont express MHC I
Have abnormal Protein expression
Ab-Coated
Complement covered
Author
KHW
ID
65577
Card Set
Exam 1
Description
Exam 1
Updated
2011-02-11T01:37:23Z
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