life span on neutrophils
4 Major parameters/cells types of the innate immune:
Soluble defense factors
Functions of TLR
Microbial recognition, engulfing & Killing
Mediate innate (inflammation)
Mediate Acquired (Humoral and CMI)
Abitility of Ag to bind to immune components
The ability of an Ag to illicit an immune response
immunogenic part that binds to Ab or TLR
After Ag is captured, immature dendritic cells migrate to...
Secondary Lymph tissues (ie LN)
After AG is captured, MATURE dendritic cells migrate to...
Secondary Lymph Tissue
Endogenous Ag presents via...
Exogenous Ag presents via...
Exogenous APCs can also present endogenous Ag if via MHC I...
MHC I: _____ Ag Processing to _____
MHC II: ____ Ag processing to _____
MHC II is expressed only by...
MHC I is expressed by...
All Nucleated Cells
MHC I is active when...
Specificity/Diversity of BCR's and TCRs is made possible by...
Somatic Gene Rearrangement
B & T cells mature within the ___ Lymph Tissue
Upon leaving the thymus, T-Cells are mature, but...
Naieve until presented by MHC-Ag complex
Th that aids other T & B cells
Tc that kill infected cells and tumor cells
Tc Ag processing and differentiation occurs in the ____ Lymph Tiss
The Tc receptor is located...
Ways in which a is T-cell activated:
Direct (TcR + MHC + Ag)
Costimulation (TcR + MHC + Ag + costim molecules)
Tc is activated by..
MHC II Ag presentation
Activation of TCells, BCells & NK
Activation of MO
Marks tumor cells
Functions of Th2 cytokines:
Stimulate B-call proliferation
Neutralizing Ab secretion
Resistance to extracellular pathogens
Infected cells (w/ endogenous Ag)
Transformed cells (tumor Ag)
MHC Incompatible cells (non-self)
B-Cells mature when...
they react with Ag
B-Cell receptor is located..
in the membrane
B-Cells are activated when
Ag binds to BCR
Th cell signal
NK cells have receptors for:
Fc part of Ab
NK Cells are regulated by:
NK Cells target cells that...
Dont express MHC I
Have abnormal Protein expression