Pharm II (Management of pain)

  1. What is the difference between Secondary to nerve injury and Nociceptive pain?
    • Secondary to nerve injury
    • -Responds poorly to opioids and NSAIDs
    • Nociceptive pain
    • -post-operative, due to trauma, arthritic
    • -Responds to opioids and NSAIDs
  2. What is Allodynia?

    What is Hyperalgesia?
    -Pain from stimulus that ordinarily does not elicit a painful response; e.g., light touch

    -Increased sensitivity to a normally painful stimulus
  3. What are some drug groups that are used in pain management?
    • TCA and SNRI antidepressent drugs
    • Antiepileptics
    • Opioids
    • Local Anesthetics
  4. SNRIs
    • NE and 5-HT reuptake inhibition
    • -Duloxetine- used for Diebetic Perioheral Neuropathy

    • Milnacipran
    • -Fibromyalgia
  5. What are the antiepileptic drugs that can be used for pain? what are they used for?
  6. -carbamazepine-Approved for trigeminal neuralgia
    • -gabapentin-PHN
    • -pregabalin-PHN, Painful diabetic peripheral
    • neuropathy, Fibromyalgia
  7. What is lidocaine used for?
    • -Topical
    • -Approved for PHN
  8. What are some other drugs that are approved for Neuropathic pain?
    • Topical capsaicin
    • -Depletes substance P
    • -Has been studied in painful diabetic peripheral neuropathy
    • Corticosteroids
    • α-2 agonists, eg, clonidine
    • α-1 antagonists, eg, prazosin, terazosin
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Pharm II (Management of pain)
Pharm II (Management of pain)