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Primary risk factor for perio disease
gingivitis/biofilm
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well-organized
cooperating
community of
microorganisms
biofilm
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Protects the bacteria from external sources
such as antibiotics/antimicrobials
Extracellular matrix
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# of baceria in biofilm
>500
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#pathogenic
< 10% pathogenic
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# normal oral microbiota
>90% normal oral microbiota
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When do u get aquired pellical?
first few hrs
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4 things in aquired pellical
- protien
- glycoprotien
- saliva
- crevicular fluid
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After aquired pellical?
subsurface pellical
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What does bacteria adhere to?
surface proteins
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Prevotella intermedia causes?
pregnancy gingivitis
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Bacteria that recognized carb structure are called?
lectins
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Bacteria in the red group?
- Pg
- Tf (Bf)
- Td (T. denticola)
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Aa is in which color?
green
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Which color groups are the first colonizers?
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Types of subg bacterial biofilms
- Tooth associated (attached)
- Tissue associated
- Unattached
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Nutrients for subg biofilm
GCF contains Hemin-containing compounds that enhance the growth of porphymonas and prevotella sp.
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GCF has a good property
Antimicrobial- prevents bacterimia and infections
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What holds biofilm together and protects the bacteria?
extracellular matrix
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Direct Effect of Bacterial Action
- Cytotoxic Agents (LPS/LOS, leucotoxins, lipoteichoic acid)
- Enzymes (MMPs)
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Indirect Effect of Bacterial Action
- Immunopatholgic Mechanisms (antigens stimulate immune response)
- Combined mechanisms
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Gram-negative bacterial cell wall
Released when bacteria die and lysis
occurs
Initiates inflammation and bone destruction
Found loosely attached to root cementum
LOS/LPS
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Components of dental plaque biofilm
- Bacteria
- Extracellular matrix
- Cells: WBC, RBC, epithelial, ghost cells
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Extracellular matrix is what % of plaque
25%
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3 groups of factors
- local factors (environment)
- systemic factors (medical conditions)
- host factors (one's own body)
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future health problems assc. with perio disease
- diabetes mellitus
- heart disease
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General term for something released by bacteria
endotoxin
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