-
Bactericidal-
Kills bacteria
-
Bacteriostatic-
Inhibits growth
-
Drug groups are based on (2):
- Mechanism of action
- Chemical Grouping
-
Ex. of Bactericidal drug (1):
Pen
-
Ex. of Bacteriostatic drug (1):
Tetracyclines
-
Aim of antibacterial drugs:
Maintain effective concentration at infection site
-
To be an effective dosage, what is required?
- 3-5x MIC at the site of infection
- (MIC= Min. Inhibitory Concentration)
-
Drug Choice is based on (5):
- Dx
- Susceptibility of agent
- Nature of infection (local, systemic)
- Pharmacokinetics (freq. based on elimination)
- Host (spp, age, pregnancy)
-
Strangles is caused by ____ and can be treated w/ ____
-
What drugs should be avoided in bunnies?
-
Ex of drug destroyed in stomach:
Pen G
-
Ex. of drug not absorbed in GI tract:
- Aminoglycosides
- (Gentamicin)
-
Pink Eye in cattle is cause by ____ and can be Tx w/ ___ or ____
- Moraxella Bovis
- Liquamycin LA or Oxytetracycline LA
-
Mech of action of antibacterial drugs (4):
- Inhib of wall synthesis
- Damage to cell membrane function
- Inhib of Nucleic Acid Synthesis/Function
- Inhib of protein synthesis
-
Drugs that inhibit synthesis of wall (2):
-
Drugs that damage cell membrane function (1):
Polymyxins
-
Drugs that inhib Nucleic Acid Synthesis/Function (3):
- Sulfonamides
- Quinolones
- Enrofloxacin
-
Drugs that inhib protein synthesis (2):
- Tetracyclines
- Aminogylcosides
-
Mechanisms employed by bacteria to resist drugs (4):
- Enzymes that destroy/inactivate drug
- Alteration of target
- Decreased cell wall perm
- Alt metabolic pathway
-
Staph Aureus drug resistance mech:
B-Lactamase against Pen
-
B-Lacam drugs (5):
- Pen G
- Ampicillin
- Amoxycillin/Clavamox
- Cephalosporins
- Ceftiofur
-
Potentiated Pen:
- Amoxi-Calvuneate
- Amoxi-Sulbactam
- (counteracts b-lactamase)
-
-
3rd Gen B-Lactams (2):
- Ceftazidime
- Ceftiofur
- Aminoglycoside Drugs (1):
- Gentamicin
-
-
Macrolide Drugs (4):
- Erythromycin
- Tylosin
- Tiamulin
- Tilmicosin
-
Aminoglycosides will kill:
Pseudomonas
-
Aminoglycosude Drugs include (5):
- Streptomycin (Oldest, most resis)
- Neomycin
- Kenamycin
- Gentamycin
- Amikacin/Tobramycin (Best)
-
Quinolones...
Narrow Spectrum (1):
Broad Spectrum (2)
- Narrow: Quinolone
- Broad: Fluoroquinolones
-
Ex. of quinolone drugs (1):
Nalidixic Acid
-
Fluoroquinolone Drugs (3):
- Cipro
- Enrofloxacin
- Orbifloxacin
-
Fluroquinolones are not effective against...
Anaerobes
-
Penn G will Tx (4):
- Strangles
- Coryne UTI (cattle)
- Tetanus
- Blackleg Prophylaxis
-
Amp/Amoxi will Tx (1):
Some Resp. Infections
-
Amoxi-calvulanate will Tx (4):
-
Ceph/Cefadroxil will Tx (2):
-
Ceftazidime/Ceftiofur will Tx(2):
-
Tx Respiratory infections w/ (3):
- B-Lactams (better)
- TMS
- Fluoroquinolones
-
Tx Pseudomonas wounds w/:
B-Lactams
|
|
