-
Benzodiazepam
- Used to relax, calm, and promote sleep
- Safer than barbiturates, less chance of lethal overdose
- Subject to tolerance and physical dependence
-
Benzodiazepam MOI
- Potentiate effects of GABA, especially GABAa
- GABAa1 has alpha (sedation)
- GABAa2,3 ( Decreased anxiety)
-
-
-
-
-
-
-
-
-
-
-
Barbiturates
- Very addictive
- Potentiate inhibitoy effects of GABA
- Bind to GABAa at a site different than GABA or Benzodiazepams
-
Zolpidem
- Ambien
- Affect GABAa1 by causing GABA to bind more effectively increasing CL= conductance and level of inhibition
- Mediates sedation without producing other side effects
-
Zaleplon
- Sonata
- Affect GABAa1 by causing GABA to bind more effectively increasing CL= conductance and level of inhibition
- Mediates sedation without producing other side effects
-
Alcohol
Activate GABA1 receptors increasing GABA mediated inhibition.
-
Buspirone
- Buspar
- Increases the effects of serotonin in areas of the brain
- Less sedation and psychomotor impairment then benzos, less risk of tolerance and phys depend
- Moderate efficacy
-
Propranolol
- Inderal
- Beta blocker that decreases anxiety probably through sympatholytic effects.
|
|
