GE5

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How much plasma is normally filtered per minute?

120 ml/min
The maximum amount of glucose that a transporter can reabsorb/minute

T_max
The amount of glucose that is filtered / minute
- "Filtered load of glucose"
- 0.6 mmol/minute
Why does glucose appear in the urine

"Filtered load of glucose" is more than T_max
These 2 conditions can cause glycosuria (starts with D and F)
- Diabetes Mellitus (high plasma [glucose] )
- Familial glycosuria (T_max is lowered)
This is reduced in old diabetics

GFR
How does all that reabsorped stuff get back into the blood once inside the cell?

Pressure going IN capillaries is more than pressure going OUT
How much blood is filtered every day?

160 L!
How much urine is excreted each day?

1.5 L
70% of filtrate is reabsorped here

Proximal tubule
20% of filtrate is reabsoped here

Loop of Henle
Salt and water balance happens here

Distal tubule
This polysaccaride is used to measure GFR

Inulin
These cells are connected by tight junctions

Epithelial cells
These cells sit on the basement membrane of capillaries

Epithelial cells
This side of the cell faces the lumen

Apical side
This side of the cell faces away from the lumen

Basolateral side
This is reabsorped in the early proximal tubule

Amino acids; Glucose; Bicarbonate
Hartnup disease (a genetic defect in protein transporters) can cause this

Amino-aciduria
This transporter is messed up in Hartnup disease
- Phenylalanine
- Alanine
- Tryptophan
- Serine
This transporter is messed up in Cistinuria
- Cystine
- Arginine
This is reabsorped in the late proximal tubule

Chlorine
What is the normal level of glucose in blood?

4-5 mmol/L
Glucose Transport:
How much glucose can you have in the plasma before it starts appearing in the urine?
- 14 mmol/L
- The transporters cant handle more than this

Author

Bobopudge

64960

Card Set

GE5

Description

Tube function

Updated

2011-03-04T14:31:38Z

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