immuno II

Antigenicity-

Ability of an Ag to bind with immune components
Immunogenicity-

Ability of an Ag to illicit an immune response
Properties of a good immunogen (4)
- Larger than 1kDa
- +Complexity
- Relatively Stable
- Foreign
Haptene-

Too small to be immunogenic in vivo
Ex. of two good Immunogens based on complexity:
- Proteins + Glycoproteins
- Lipids + Nucleic Acids (sometimes)
Epitope-

Small part of immunogenic molecule that binds to Ab or TLR
Cross Reactivity-

When an Ab recognizes/reacts to a similar epitope
Ex of Cross Reactivity (3):
- Blood Types
- Brucella abortus & Y. enterocolitica
- Multiple Sclerosis
Acquired Immune Sys is activated by...
- Capture, processing and presentation by APCs
- (antigen presenting cells)
T-Cells are activated by:

MHC presentation to the TCR
T Cytotoxic cells are activated by...

MCH I
T Helper cells are activated by...

MCH II
B-Cells are activated by:

BCRs recognize and bind Ag (w/o special presentation), but still requires T-h to procudes Ab
Cells that present exogenous Ag via MCH II:
- Dendritic
- Macrophages
- B-Cells
Only ____ can present to naieve T cells

Dendritic
After caputring Ag _____ dendritic Cells migrate to lymphoid tissue

Immature
_____ dendritic cells process and present Ag in lymph nodes

Mature
Exogenous APCs can present endogenous APCs via MCH I when?

When intracellularly infected

Author

HLW

64879

Card Set

immuno II

Description

test1, II

Updated

2011-02-08T03:56:07Z

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