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Federal government roles in the regulation of medications
is to protect the health of the people by ensuring that medications are safe and effective. Currently the FDA ensures that all medications undergo vigorous testing before they are sold.
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State government roles in the regulation of medications
conform to federal legislation but also have additional controls such as alcohol and tobacco.
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Health care institutions and the roles in the regulation of medications
individual policies to meet federal and state regulations.
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Nurse Practice Act
define the scope of a nurse’s professional functions and responsibilities.
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Chemical name
provides an exact description of the medication’s composition and molecular structure
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Generic name
manufacturer who first develops the medication, which becomes the official name
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Brand/ Trade name
the manufacturer has trademarked the medication’s name
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A medication classification indicates
indicates the effect of the medication on a body system, the symptoms the medication relieves, or the medication’s desired effect
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The form of the medication determines its
determines its route of administration
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Pharmacokinetics
is the study of how medications enter the body, reach their site of action, metabolize, and exit the body
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Absorption is
refers to the passage of medication molecules into the blood from the site of administration
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What factors influence drug absorption
- a. route of administration
- b. ability of the medication to dissolve
- c. blood flow to the site of administration
- d. body surface area
- e. lipid solubility
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Factors that affect the rate and extent of medication distribution
- a. circulation
- b. membrane permeability
- c. protein binding
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The role of metabolism
occurs under the influence of enzymes that detoxify, degrade, and remove biologically active chemicals, mostly in the liver
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What is the primary organ for drug excretion
the kidneys; when renal function declines, a client is at risk for medication toxicity
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Therapeutic effects
is the expected or predictable physiological response to a medication
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Side effects
are the unintended, secondary effects a medication predictably will cause
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Adverse effects
are severe responses to medication
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Toxic effects
develop after prolonged intake of a medication or when a medication accumulates in the blood because of impaired metabolism or excretion
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Idiosyncratic reactions
unpredictable effects in which a client overreacts or underreacts to a medication or has a reaction different from normal
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Allergic reactions
are predictable responses to a medication
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Anaphylactic reactions
allergic reactions that are life-threatening and characterized by sudden constriction of bronchiolar muscles, edema of the pharynx and larynx, and severe wheezing and shortness of breath
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A medication interaction is:
when one medication modifies the action of another medication
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A synergistic effect is:
The combined effect of the 2 medications is greater than the effect of the medications when given separately
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Serum concentration
constant blood level within a safe therapeutic range
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Peak concentration
highest serum concentration
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Serum half-life
is the time it takes for excretion processes to lower the serum medication concentration by half
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Onset of drug action
time it takes after a medication is administered for it to produce a response
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Peak action
time it takes for a medication to reach its highest effective concentration
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Trough
minimum blood serum concentration of medication reached just before the next scheduled dose
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Duration of action
time during which the medication is present in concentration great enough to produce a response
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Pateau
blood serum concentration of a medication reached and maintained after repeated fixed doses
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3 types of oral routes
- a. oral
- b. buccal
- c. sublingual
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4 major sites for parenteral injections
- a. intradermal
- b. subcutaneous
- c. intramuscular
- d. intravenous
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Epidural
administered in the epidural space via a catheter, usually used for post-op analgesia
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Intrathecal
a catheter that is in the subarachnoid space or one of the ventricles of the brain
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Intraosseous
infusion of medication directly into the bone marrow, commonly used in infants and toddlers
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Intraperitoneal
into the peritoneal cavity such as chemotherapeutic agents, insulin, and antibiotics
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Intrapleural
directly into the pleural space, commonly chemotherapeutics
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Intraarterial
directly into the arteries
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Intraarticular
injection of a medication into a joint
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5 methods for applying medication to mucous membranes
- a. directly applying a liquid or ointment
- b. inserting a medication into a body cavity
- c. instilling fluid into a body cavity
- d. irrigating a body cavity e. spraying
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Intracardiac
injection directly into the cardiac tissue
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What is the benefit of the inhalation route
They are readily absorbed and work rapidly because of the rich vascular alveolar capillary network present in the pulmonary tissue
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3 types of measurement used in medication therapy
- a. metric
- b. apothecary
- c. household
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A solution is :
given mass of solid substance dissolved in a known volume of fluid or a given volume of liquid dissolved in a known volume of another fluid
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Verbal medication order
if the order is given verbally to the nurse by the provider
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Standing or routine medication order
is carried out until the prescriber cancels it by another order or until a prescribed number of days elapse
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prn
a medication that is given only when a client requires it
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single (one-time)
a medication that is given only once at a specified time
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STAT
single dose of a medication to be given immediately and only once
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Now:
is used when a client needs a medication quickly but not right away; nurse has up to 90 minutes to administer
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What are the medication distribution systems
- a. unit dose
- b. automated medication dispensing systems (AMDS)
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What are the common medication errors that can cause client harm
inaccurate prescribing, administration of the wrong medicine, giving the medication using the wrong route or time interval, and administering extra doses or failing to administer a medication
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What is the process for medication reconciliation
- a. verify
- b. clarify
- c. reconcile
- d. transmit
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What are the 6 rights of medication administration
- a. the right medication
- b. the right dose
- c. the right client
- d. the right route
- e. the right time
- f. the right documentation
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What are the Patient Care Partnership related to medication administration
- a. be informed of the medication’s name, purpose, action, and potential undesired effects
- b. refuse a medication regardless of the consequences
- c. have qualified nurses or physicians assess a medication history
- d. be properly advised of the experimental nature of medication therapy and give written consent
- e. receive labeled medications safely without discomfort
- f. receive appropriate supportive therapy g. not receive unnecessary medications h. be informed if medications are a part of a research study
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What areas does the nurse need to assess to determine the need for and potential response to medication therapy
- a. history
- b. history of allergies
- c. medication data
- d. diet history
- e. client’s perceptual coordination problems
- f. client’s current condition
- g. client’s attitude about medication use
- h. client’s knowledge and understanding of medication therapy
- i. client’s learning needs
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What are some nursing diagnoses used during the administration of meications
1. anxiety
2. health maintenance, ineffective
3. health-seeking behaviors
4. deficient knowledge
5. noncompliance
6. disturbed visual sensory perception
7. impaired swallowing
8. effective therapeutic regimen management
9. ineffective therapeutic regimen management
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Identify factors that can influence the client's compliance with medication regimen
health beliefs, personal motivations, socioeconomic factors, and habits
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What are the outcomes for a client with newly diagnosed type 2 diabetes
- a. will verbalize understanding of desired effects and adverse effects of medications
- b. will state signs, symptoms, and treatment of hypoglycemia
- c. to monitor blood sugar to determine if medication is appropriate to take
- d. establish a daily routine that will coordinate timing of medication with meal times
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What are the components of medication orders
- a. client’s full name
- b. date and time that the order is written
- c. medication name
- d. dose
- e. route of administration
- f. time and frequency of administration
- g, signature of provider
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The recording of medications incluedes
the name of the medication, dose, route, and the exact time of administration and site
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What are the precautions to take when administering any oral preparaion
1. a. Determine the client’s ability to swallow.
b. Assess the client’s cough.
c. Determine the presence of a gag reflex.
d. Prepare oral medications in the form that is easiest to swallow.
e. Allow the client to self-administer medications if possible.
f. If the client has unilateral weakness, place the medication in the stronger side of the mouth.
g. Administer pills one at a time, ensuring that each medication is properly swallowed before the next one is introduced.
h. Thicken regular liquids or offer fruit nectars if the client cannot tolerate thin liquids.
i. Avoid straws because they decrease the control the client has over volume intake, which increases the risk of aspiration.
j. Have client hold cup and drink from cup if possible.
k. Time medications to coincide with mealtimes or when the client is well-rested and awake if possible.
l. Administer medications using another route if risk of aspiration is severe.
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What is the most common form of nasal instillation
decongestant spray or drops
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4 principles for administering eye instillations
- a. avoid instilling any eye medication directly onto the cornea
- b. avoid touching the eyelids or other eye structures with eye droppers or ointment tubes
- c. use medication only for the client’s affected eye
- d. never allow a client to use another client’s eye medications
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Failure to instill ear drops at room temp causes:
vertigo, dizziness, nausea
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Vaginal medications are available as:
suppositories, foam, jellies, or creams
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Rectal suppositories are used for:
exerting local effects (promoting defecation) or systemic effects (reducing nausea)
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Metered-dose inhalers (MDIs):
delivers a measured dose of medication with each push of a canister often used with a spacer
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Dry power inhalers (DPIs)
hold dry, powdered medication and create an aerosol when the client inhales through a reservoir that contains the medication
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What are the aseptic techniques to use to prevent an infection during an injection:
1. Draw medication from ampule quickly; do not allow to stand open.
2. Avoid letting needle touch contaminated surface.
3. Avoid touching length of plunger or inner part of barrel.
4. Prepare skin, use friction and a circular motion while cleaning with an antiseptic swab, and start from the center and move outward.
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What are the factors that must be considered when selecting a needle for an injection:
- a. the client’s size and weight
- b. type of tissue into which the medication is to be injected
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Ampule
contain single doses of medications in a liquid
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Vial
is a single dose or multidose container with a rubber seal at the top (closed system)
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What are the 3 principles to follow when mixing medications from two vials:
- a. do not contaminate one medication with another
- b. ensure that the final dose is accurate
- c. maintain aseptic technique
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Insulin is classified by:
rate of action (rapid, short, intermediate, and long-acting); each has a different onset, peak, and duration of action
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What are the principles when mixing two kinds of insulin in the same syringe
- a. need to maintain their individual routine when preparing and administering their insulin
- b. do not mix insulin with any other medication or diluents
- c. never mix insulin glargine or insulin detemir with other types of insulin
- d. inject rapid-acting insulin mixed with NPH within 15 minutes before a meal
- e. do not mix short-acting and lente insulins unless the blood glucose levels are currently under control with this mixture
- f. do not mix phosphate-buffered insulins with lente insulins
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What are the techniques to minimize client discomfort that is associated with injections
- a. use a sharp beveled needle in the smallest suitable length and gauge
- b. position the client as comfortably as possible to reduce muscle tension
- c. select the proper injection site
- d. divert the client’s attention from the injection
- e. insert the needle quickly and smoothly
- f. hold the syringe while the needle remains in tissues
- g. inject the medication slowly and steadily
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What are the best sites for subcutaneous (sub-Q) injections
the outer posterior aspect of the upper arms, the abdomen (below the costal margins to the iliac crests), and the anterior aspects of the thighs
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What is the maximum amount of water-soluble medication given by the Sub-Q route?
0.5 to 1 ml
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What angles should be utilized when administering a Sub-Q injection
- 25-gauge, 5/8 inch needle inserted at a 45-degree angle
- or a ½ inch needle inserted at a 90-degree angle
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What is the angle of insertion for an intramuscular (IM) injection
90 degrees
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What is the maximum volume of medication for IM injections for a Well-developed adult:
3 ml into a large muscle
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What is the maximum volume of medication for IM injections for Older children, older adults or thin adults:
2 ml
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What is the maximum volume of medication for IM injections for Older infants and small children:
1 ml
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Vastus lateralis
lacks major nerves and blood vessels; rapid absorption; frequently used in infants, older children, and toddlers (immunizations)
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Ventrogluteal
deep site away from nerves and blood vessels, less chance of contamination, easily identified landmarks, preferred site for medications
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Deltoid
easily accessible but muscle not well developed, use small amounts, not used in infants or children, potential for injury to radial and ulnar nerves, immunizations for children, recommended site for hepatitis B and rabies injections
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What is the rationale for the Z-track method in IM injections
minimizes local skin irritation by sealing the medication in muscle tissue
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What is the rationale for intradermal injections
skin testing, injected into the dermis where medication is absorbed slowly
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What are the methods a nurse can use to administer medications intravenously
- a. as mixtures within large volumes of IV fluids
- b. injection of a bolus or small volume of medication
- c. piggyback infusion
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What are the advantages of the intravenous route of administration
- a. fast-acting medications must be delivered quickly
- b. constant therapeutic blood levels
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What are the disadvantages of IV bolus medications
- a. most dangerous method because there is not time to correct errors
- b. a bolus may cause direct irritation to the lining of blood vessels
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What are the advantages of using volume controlled infusions
- a. it reduces risk for rapid-infusion by IV push
- b. allows for administration of medications that are stable for a limited time in solution
- c. it allows for control of IV fluid intake
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Piggyback set
a small (25-250 ml) IV bag connected to short tubing lines that connects to the upper Y port of a primary infusion line
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Tandem setup
small (25-100 ml) IV bag connected to a short tubing line to the lower Y port of a primary infusion
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Volume-control administration set
small (50-150 ml) containers that attach below the primary infusion bag
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miniinfusion pump
battery-operated and allows medications to be given in very small amounts of fluid (5-60 ml)
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3 advantages of using intermittent venous access devices
cost-saving, convenience, increased mobility, safety, and comfort for the client
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The study of how drugs enter the body, reach their sites of action, are metabolize, and exit from the body is called:
Pharmacokinetics
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What statement correctly characterizes drug absorption
- Most drugs must enter the systemic circulation to have a therapeutic effect
- ** absorption refers to the passage of medication molecules into the blood from the site of administration
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the onset of drug action is the time it takes for a drug to :
Produce a response
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Which is not a parental route of administration,
a. Buccal
b. Intradermal
c. Intramuscular
d. Subcutaneous
Buccal is wrong, this is an oral route
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The nurse is preparing an insulin injection in which both regular and NPH will be mixed. Into which vial should the nurse inject air first?
a. the vial of regular insulin
b. the vial of NPH
c. Either vial, as long as modified insulin is drawn up first
d. Neither viral; it is not necessary to put air into vials before withdrawing medication
- B-the vial of NPH
- **if mixing rapid- or short-acting insulin with intermediate or long-acting insulin, take insulin syringe and aspirate volume of air equivalent to the dose of insulin to be withdrawn from the long-acting insulin first
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