-
Neonatal respiratory distress can be caused by obstruction at any of the following locations
- Nasal vestibule, piriform aperature, choanae
- Oral cavity (macroglossia, glossoptosis)
- Oropharynx (lingual thyroid, dermoid, vallecular cyst, hemangioma, lymphangioma)
- Larynx (supraglottic, glottic, subglottic abnormalities)
- Tracheobroncheal anomalies
-
Infant larynx is different from adults by:
- High position in the neck (tip of epiglottis is at C2/3)
- Larynx is more anterior
- Subglottis/cricoid is narrowest portion of airway
- Membranous portion of VC is 2/3 of true cord
- Epiglottis is omega shaped
- Pharyngeal structures are closer together
-
Anatomic dimensions of pediatric airway
- Vocal cords are 6 to 8 mm long
- Vocal processes of the arytenoid cartilage extend 3 - 4 mm
- Posterior glottis has a transverse length of 4 mm
- Subglottis has a diameter of 5 to 7 mm
- Trachea is 4 cm long; diameter of 3.6 mm
- Ratio of cartilaginous to membranous trachea is 4.5 to 1
-
1mm reduction in diameter of the pediatric airway will cause how much obstruction?
35%
-
Phases of swallowing:
- Preparatory
- Oral
- Pharyngeal
- Esophageal
Swallowing reflex is regulated by the brainstem in the newborn
-
Features of pediatric swallowing
- Infant swallowing undergoes orderly maturation process
- Prior to 34th week of gestation, poor coordination and insufficient suckling response
- Neuromuscular maturation thereafter allows full-term infants to suckle at birth
-
Differences in swallowing structures
- Hard palate is closer to the skull base
- Larynx is higher
- Adenoid pad, tonsils and tongue are relatively larger
- Nasopharyngeal closure requires less angulation of the soft palate
- Tonsils and tongue assist in oropharyngeal propulsion
-
Airway protection during swallowing is maintained by:
- 1. Oropharyngeal swallow mechanisms (e.g. nasopharyngeal closure, palatopharyngeal strucutures direct the food into the hypopharynx; pharynx and larynx elevate
- 2. Laryngeal "sphincter": epiglottis, aryepiglottic olds, and arytenoid cartilages, false folds, true vocal folds
- 3. Mucociliary clearance and cough reflex
-
History for pediatric airway concerns should include:
- SPECS-R
- severity, progression, eating difficulties (swallowing, GER, aspiration), cyanosis +/- ALTE, sleep disturbances/SDB, radiologic findings
-
Laryngeal findings of GERD/LPR
- posterior glottic edema
- arytenoid edema
- enlargement of the lingual tonsils
- granular exudate on TVC surface
- Irregular contact edges
- Deep shelf of posterior laryngeal tissue/induration
- Posterior interarytenoid rugae
-
Clinical Features of Laryngomalacia
- Most common cause of stridor during infancy
- Symptoms present weeks to months after birth
- Resolve by 12 to 1 months of age
- Stridor is usually low-pitched with a fluttering quality
-
Classification of Laryngomalacia
Type I - aryepiglottic folds are tightened or foreshortened
Type II - redundant soft tissue in any area of the supraglottic region
Type III - associated with NMD or GER
-
Laryngomalacia affects
- The epiglottis, arytenoid cartilages or both
- If epiglottis - elongated, walls fold in on themselves; omega-shaped
-
Recurrent Respiratory Laryngeal Papillomatosis is cause by which HPV subtypes
HPV 6, 11, 16, 18
-
Risk factors for RRP
- First born, male
- Maternal or paternal genital condylomata
- Lower socioeconomic class
- Multiple sexual partners
- Younger maternal age
-
RRP is categorized into...
Juvenile onset (JORPP) <12 yrs of age
Adult onset (AORPP) >12 yrs of age
-
Incidence of RRP
0.24 to 1.11 per 100,000
-
Transmission of RRP
- Vertical transmission from anogenital tract afected with condylomata (active or inactive)
- Active = Risk of 231 x
- Long labour increases risk 2x
- Other factors: patient immunity, volume of viral exposure, lenght of exposure, local traumas
-
Primary Ciliary Dyskinesia presents...
- Ages 4 months to 41 years
- Chronic sputum production
- Nasal symptoms
- Cough
- Sinusitis
- Otitis media
-
Newborn presentation of PCD
- Newborn rhinitis
- Dextrocardia
- Situs inversus
- Esophageal atresia
- Biliary atresia
- Hydrocephalus
- Positive family history
-
Presentation of PCD in older children
- Atypical asthma
- Severe GERD
- Rhinosinusitis +/- polyps
- Bronchiectasis
- Chronic and severe secretory otitis media
- Chronic otorrhea with tympanostomy tubes
-
Adult presentation of PCD
- Infertility
- Immotile sperm
-
Investigations for Primary Ciliary Dyskinesia
- CXR
- CT-Chest
- Sweat test
- IgG, IgE
- RF, ANA,
- Alpha-1 antitrypsin levels
- Esophageal monitoring
- Fiberoptic bronchoscopy
-
The Saccharin test
- Screening for PCD
- Measure of mucociliary clearance
- Saccharin is placed on inferior turbinate
- If time to tasting is >60 minutes, positive
|
|