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Beta lactam MOA
Inhibits cell wall synthesis.
-
Penicillin drugs (3)
- Penicillin VK - Veetids
- Amoxicillin - Amoxil
- Amoxicillin/clavulanate - Augmentin
-
Penicillin Indications
AOM, ABS, UTI, pharyngitis
-
Cephalosporins (3)
- Cephalexin - Keflex
- Cefuroxime - Ceftin
- Cefdinir - Omnicef
-
Cephalosporins indications
cellulitis, ABS, AOM, gonorrhea
-
Beta-lactam counseling points
- Side effects: N/V/D
- Allergies: Rash vs anaphylaxis
-
Sulfonamides MOA
Inhibits folate synthesis
-
Sulfonamides drugs (2)
- Sulfamethoxazole - Bactrim
- Trimethoprim - Sulfatrim
-
Sulfonamide indications
UTI, AOM, PCP
-
Sulfonamide counseling points
- Side effects: N/V/D, stevens-johnson syndrome
- Not for use in pregnant women
- CYP450 inhibitor
-
Macrolide MOA
Binds ribosome and inhibits protein synth
-
Macrolide drugs (3)
- Azithromycin - Zpak
- Erythromycin - Ery-Tab
- Clarithromycin - Biaxin
-
Macrolide indications
CAP, U/LRI, chlamydia
-
Macrolide counseling points
- Azithromycin - avoid antacids
- Erythro/Clarithro - avoid grapefruit
- Side effects: N/V/D
- CYP450 inhibitor
-
Fluoroquinolone MOA
Inhibits DNA replication/transcription
-
Fluoroquinolone drugs (3)
- Ciprofloxacin - Cipro
- Levofloxacin - Levaquin
- Moxifloxacin - Avelox
-
Fluoroquinolone indications
- UTI, CAP, ABS
- Cipro - anthrax
-
Fluoroquinolone counseling points
- No antacids/dairy
- Side effects: N/V/D, increased blood sugar in DM
- Rare - tendon toxicity
- DI: warfarin/caffeine
-
Tetracycline MOA
Binds ribosome and inhibits protein synth
-
Tetracyclines drugs (3)
- Tetracycline - Sumycin
- Doxycycline - Vibramycin
- Minocycline - Minocin
-
Tetracycline indications
Acne, skin infections, STDs
-
Tetracycline special administration
- Take with full glass of water and sit up for 30 mins.
- Avoid antacids/dairy
- Never take expired medication
-
Tetracycline counseling points
- Side effects: N/V/D, indegestion
- Not for use in pregnant women or children
- DI: warfarin
-
Lincosamide MOA
Binds ribosome and inhibits protein biosynth
-
Lincosamide drug (1)
Clindamycin - cleocin
-
Lincosamide indications
Upper GI, bacterial vaginosis, topical for acne
-
Lincosamide counseling points
- Side effects: N/V/D
- Black box warning for C. difficile associated diarrhea and Pseudomembranous colitis.
-
Nitroimidazole MOA
Destroys DNA structure
-
Nitroimidazole drug (1)
Metronidazole - flagyl
-
Nitroimidazole indications
C. difficle associated diarrhea, bacterial vanginosis, upper GI
-
Nitroimidazole counseling points
- No alcohol!
- Side effects: dysuria, discolored urine
- Not for use in pregnant women
-
Nitrofurantoin MOA
Inhibit acetyl CoA
-
Nitrofurantoin drug (1)
Nitrofurantoin - macrobid
-
Nitrofurantoin indications
UTI
-
Nitrofurantoin counseling points
- Side effects: N/V/D, discolored urine
- Not for use in renal impairment cases
- No magnesium salts
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