-
atropine
- muscarinic antagonist
- bronchodilation
- decreased motility of GI tract
- raises HR
- decreased salivation/sweating
-
buspirone
- 5-HT1A partial agonist
- relaxation of proximal stomach, alleviates dyspepsia
- SE: nausea, headache, dizziness
-
cimetidine
- histamine H2 receptor antagonist
- treatment of GERD, hypersecretion of acid
- inhibits many CYP450s
-
erthyromycin
- antibiotic, motilin agonist
- treatment for respiratory/soft tissue infections, gastroparesis (pro-motility effect)
-
fluoxetine
- SSRI antidepressant
- b/c it blocks reuptake of 5HT, has the SE of GI discomfort, nausea, headache, insomnia, anxiety, diarrhea
-
metoclopramide
- prokinetic drug
- treats reflux esophagitis, induces gastric emptying, helps chemo-induced nausea
- 5HT3 antagonist, 5HT4 agonist
- increase ACh (indirectly) in gut
- D2 receptor antagonist
- SE: diarrhea, depression
-
misoprostol
- prostagladin E1 analog
- prevention of gastric and duodenal ulcers secondary to NSAID use
- mucosal protectant effect
- SE: diarrhea, abd pain, dyspepsia
-
neostigmine
- AChE I carbamate-type
- increases gastric motility, treats paralytic ileus, lack of bladder tone
- SE: diarrhea, bowel cramps
-
octreotide
- somatostatin analog
- treats diarrhea and abd illness, acromegaly, orthostatic hypotension
- antidiarrheal, inhibits gastric acid and pepsin secretion
-
Omeprazole
- PPI (proton pump inhibitor)
- treats GERD, doudenal ulcer, hypersecretory states (Zollinger-Ellison syndrome)
- blocks production of acid by irrev. binding H+/K+ ATPase
-
ondansetron
- 5HT3 antagonist (granisetron same class)
- treatment of nausea/vomiting after chemo
- SE: constipation, headache
-
rantidine
- histamine H2 receptor antagonist
- treats GERD, ulcers
- more potent than cimetidine!!
- SE: diarrhea, dizziness, rash - fewer SE than cimetidine
-
sumatriptan
- 5HT1B/1D/1P agonist
- treats dyspepsia, migraine
- fundal relaxation, reduce antral motility, vasoconstrictor
- SE: flushing, dizziness, weakness, nausea, stiffness, tingling
-
sucralfate
- cytoprotectant, mucosal coating agent
- treats ulcers, inhibits pepsin
- SE: constipation
-
antacids
- Al(OH)2, CaCO3, etc.
- neutralize acids
- simethicone - antiflatulent agent
- SE: constipation
-
oxybutynin (Ditropan)
- anticholinergic, antimuscarinic
- bladder muscle relaxant
- suppresses urge to void
- SE: dry eyes, hyposalivation, decreased gastric motility, constipation
-
tolterodine (detrol)
- anticholinergic, antimuscarinic
- same class as oxybutrin, bladder muscle relaxant
-
amitriptyline (Elavil)
- tricyclic antidepressant (TCA)
- bladder relaxant
- blocks reuptake of NE and 5HT @ nerve terminal
- SE: anticholinergic effects
-
alpha adrenergic antagonists
- benign prostatic hyperplasia (BPH)
- alfuzosin, doxazosin, tamsulosin, terazosin
- relaxes smooth muscle of prostate and bladder neck
-
vasodilators
pulmonary arterial hypertension, male erectile dysfunction
-
5-alpha reductase inhibitors
- treatment of benign prostatic hyperplasia (BPH)
- SE: sexual dysfunction, gynecomastia
-
colchicine
- antiinflammatory durg for gout
- binds to microtubules in neutrophils, prevents migration in response to uric crystal deposition
-
allopurinol
- antigout- xanthidine oxidase inhibitor
- also acts as a muscarinic antagonist
-
probenecid
- uricosuric drug
- treats hyperuricemia assoc. w/chronic gout
- inhibits reabsorption at PCT
-
sulfinpyrazone
- uricosuric drug
- treats chronic/intermittent gouty arthritis
- inhibits reabsorption of uric acid
-
disulfiram
- management of ethanol abuse
- negative-reinforcer
- inhibits oxidation of acetaldehyde - increase adverse effects of acetaldehyde buildup
|
|
