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Biochem oxidative phosphorylation
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Inhibitors of Complex I in ETC?
Amobarbital
Rotenone
Piericidin A
Inhibitors of Complex II
TTFA
Carboxin & Malonate
Inhibitor of Complex III
Antimycin A
Inhibitor of Complex IV
Cyanide
CO
Sodium Azide
Hydrogen Sulfide
Uncoupling agents
Aspirin(salicylic acid)
2,4 DNP
Purpose of uncoupling agents?
Thermogenic agents
Oligomycin?
Blocks ATP synthase
How do 2,4 DNP and Aspirin cause uncoupling between ETC and phosphorylation?
by making the inner mitochondrial membrane leaky, allowing H+ to diffuse into the matrix without going thru the ATP synthase
Atractyloside
Blocks ATP/ADP transporter in the inner mitochondrial membrane
What are two ways of transporting NADH into the inner mitochondrial membrane?
1.reducing DHAP to glycerol 3 phosphate which then enters matrix and reduces FAD
2. Oxaloacetate is reduced to malate which then enters matrix and reduces NAD+
Which complexes pump H+ into the intermembranous space?
I, III, IV
Whats the rate determining step of TCA cycle?
isocitrate dehydrogenase
Whats the rate determining step of glycolysis?
Phosphofructokinase-1 (PFK-1)
Whats the rate determining step of Gluconeogenesis
Fructose 1,6 bisphosphotase
What blocks Complex I?
Amytal
Rotenone
What blocks complex III
Actimyocin A
What blocks Complex IV
CN
CO
H2S
NAN3
What blocks ATP synthase?
Oligomycin
What are 2 uncoupling agents?
2,4-DNP
Aspirin
Whats the only lipid component of the ETC?
Coenzyme Q ---Ubiquinone
How many protons are pumped out per a pair of electrons that go thru the ETC?
10
How many protons are pumped out per a pair of electrons when complex one is omitted?
6
Which part of the ATP synthase exhibits ATP synthase activity?
F1
Author
pszurnicki
ID
64144
Card Set
Biochem oxidative phosphorylation
Description
Biochem oxidative phosphorylation
Updated
2011-02-07T17:11:35Z
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