Drugs affecting diuresis

  1. What are the 2 major applications of diuretics?
    • (1) treatment of hypertension
    • 2) mobilization of edematous fluid (associated with heart failure, cirrhosis, and kidney disease).
    • 3) In addition, because of their ability to maintain urine flow, diuretics are used to prevent renal failure.
  2. What are the 4 major categories of diuretics?
    • 1) high-ceiling (loop) diuretics (eg, furosemide);
    • (2) thiazide diuretics (eg, hydrochlorothiazide);
    • (3) osmotic diuretics (eg, mannitol); and
    • (4) potassium-sparing diuretics.
  3. How do diuretics work?
    decrease reabsorption of sodium and water along the renal tubules of the nephron in the kidney
  4. What is an example of a loop diuretic
    furosemide (Lasix)
  5. What does lasix promote the excretion of
    • K
    • Na
    • Cl
    • H20
  6. Lasix is used to treat:
    • Hypertension (especially if renal disease is present)
    • pulmonary edema
    • Heart failure
    • edema of hepatic, cardiac, or renal origin that has been unresponsive to less efficacious diuretics
  7. What are the adverse effects of a loop diuretic
    • hyponatremia
    • hypochloremia
    • dehydration
    • hypotension
    • hypokalemia
    • ototoxicity (hearing impairment, rare)
    • hyperglycemia
  8. Loop diuretics are in what pregnancy category
  9. ***Furosomide administration should occur no faster than 80mg/2min
  10. What is an example of a thiazide diuretic?
    Hydrochlorothiazide (HCTZ)
  11. How does HCTZ work?
    • –Weak diuretic that acts in the distal tubule
    • –Increases the excretion of sodium, chloride, potassium, and water
  12. What is the principle difference between high-cieling diuretics and thiazides?
    that the maximum diuresis produced by the thiazides is considerably lower than the maximum diuresis produced by the high-ceiling drugs.
  13. What are the therapeutic uses of thiazide diuretics
    • edema
    • hypertension
    • diabetes insipidus
  14. What are the adverse effects of thiazide diuretics
    • hypnatremia
    • hypochloremia
    • hypokalemia
    • dehydration
    • hyperglycemia
    • GI: nausea, vomiting
    • CNS: dizziness, vertigo
    • polyuria, nocturia
    • CV: orthostatic hypotension
  15. **thiazides should not be used during pregnancy
    **should not be used if pt has pre existing renal disease because it can slow the GFR
  16. If a pt is taking a thiazide diuretic, the nurse should
    • monitor I & O
    • weight
    • BP and Pulse
    • electrolyte levels
    • glucose levels
  17. What are the 2 sub categories of K-sparing diuretics?
    aldosterone antagonists and nonaldosterone antagonists.
  18. *** K-sparing diuretics have the weakest diuretic effect of the diuretics if given alone, but works synergistically with other diuretics
  19. What is an example of an aldosterone antagonist diuretic?
    spironolactone blocks the actions of aldosterone in the distal nephron.
  20. What is an example of a nonaldosterone antagonist
    triamterene and amiloride
  21. How does Spironolactone work?
    • works in the distal tubule to promote sodium and water excretion
    • promotes re-absorption of Potassium
  22. What are the therapeutic uses of Spironolactone?
    • Edema
    • Hypertension
    • Heart failure
  23. What are the adverse effects of Spironolactone?
    • benign and malignant tumors
    • Endocrine disorders (gynecomastia, menstrual irregularities, impotence, hirsutism, and deepening of the voice.)
    • hyperkalemia
  24. What are the adverse effects of triamterene?
    Relatively common side effects include nausea, vomiting, leg cramps, and dizziness.
  25. What is an example of a Osmotic Diuretic
    Mannitol (Osmitrol)
  26. What are some therapeutic uses of Osmotic Diuretics
    • Decrease in Intracranial Pressure
    • Decrease of Intraocular pressure
    • treatment of acute renal failure
  27. What are the adverse effects of Mannitol?
    • Serious fluid electrolyte imbalance
    • may induce fluid overload
  28. Carbonic Anhydrase inhibitors are used for?
    •Used primarily in treating chronic, open-angle glaucoma
  29. How does mannitol work?
    Draws water into the vascular space through osmosis
  30. Triamterene works where?
    in the distal tubule of the kidney
Card Set
Drugs affecting diuresis
drexel pharm