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1st Characteristic of a Steroid Hormone
Hydrophobic and therefore xported via albumin or some other xport prot.
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2nd characteristc of a Steroid Hormone
Free form is active
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3rd characteristc of a Steroid Hormone
Total [Hormone] is measred
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4th characteristc of a Steroid Hormone
Have a long 1/2 life <vs other hormones> and is measered in hours <vs minutes>
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5th Clinical Chemistry Endocrinology
Metabolism by Carboxilation, oxidation, reacting w/ SO4 &/or Glucoronic Acid to make water soluble
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6th Clinical Chemistry Endocrinology
Some have Dinural variation (ex. Cortisol)
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1st characteristic of a Peptide Hormone
Hydrophilic :. ported in blood in free state
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2nd characteristic of a Peptide Hormone
1/2 life measured in minutes
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3rd characteristic of a Peptide Hormone
No dinural variation.
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4th characteristic of a Peptide Hormone
Measured in total [hormone]
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5th characteristic of a Peptide Hormone
Share a common structure. Usually simialr alpha subunit with different betas.
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1st Hormone receptor Char.
Very Specific
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2nd Hormone receptor Char.
Equilibrium system (ie reaction is reversible)
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3rd Hormone receptor Char.
can be saturated. (due to limited #, an incr in horm will incr reaction until all recepters are in use, that is saturated)
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4th Hormone receptor Char.
High affinity. even at [low], they will still bind to receptor
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5th Hormone receptor Char.
# can vary due to dis, physiology, etc
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6th Hormone receptor Char.
dysfunc of recpt can be caused by many dis lead to horm being unable to recog and bind.
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ADH stands for
antidiuretic hormone
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ADH Action
Retain H2O & (Dcr Na)
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Target of Oxytocin
Breast Tissue
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Func of Oxytocin
Contract breast tissue to secrete Milk
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GHRF stands for
Growth Hormone Releasing Factor
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GHIF stands for
Growth Hormone Inhib Factor
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GHRF/GHIF targets
Pituitary
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GHRF function
Release of GH from Pituitary
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GH stands for
Growth Hormone
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GH comes from
the pituitary gland
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GH func
Gluc/fat metab & general body Growth
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TRF =
Thyrotropin releasing factor
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TRF func
releases TSF from pituitary
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TSF =
Thyroid Stim. factor
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TSF func
Release of T3/T4
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T3/T4
Regs metab rate of all body tiss.
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Stomatostatin from
Panc D cells
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Stomatostatin func
Facil tiss growth
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Catocholoamines from
Adrenal Medulla
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Catocolamines func
Reg blood prs, CNS activity, En metab. (Fight/Flight reaction)
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ACTHRF =
Adrenocortotropic Hormone Releasing Factor
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ACTHRF targets?
Anterior Pituitary
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ACTHRF func
stim pituitary to release ACTH
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ACTH =
Adrenocortotropic hormone
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ACTH targets
Adrenal gland
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ACTH func
Release of Cortisol
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Cortisol from
Adrenal gland
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Cortisol func
H2O & e-Lyte balance; incr gluconeogenolysis
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gastrin func
secr of gastric acids
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secretin func
antag to gastric secr & incr pancr secrtion
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ADH =
Antidiuretic Hormone
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ADH targets
- pituitary for storage;
- Kidneys & Adrenal cortex later
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ADH to kidney func
water retension
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ADH to adrenal cortex func
stims secr of aldosterone
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aldosterone from
Adrenal cortex
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aldosterone func
water & Na retentiond, as well as K
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GRH=
Ganodatropin Releasing hormone
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GRH targets
pituaitary gland
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GRH func
Release LH & FSH
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FSH & LH targets
1° sex organs
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LH funcs
Release of Progestirone & Testosterone
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FSH func
Release of Testosterone and Estorgen
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Progesterone from
ovaries
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progesterone func
stim ovulation process
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estrogen func
Maintain pregs & 2° sex char of females
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testosterone from
testies
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testosterone func
spermatogenesis & 2° char of males
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prf func
secr of prolactin
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prolactin target
breast tiss
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oxytocin eventual target
pituit for storage; breast and uterus
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oxytocin func
- breast: contract and expluse milk
- uterus: uterine contraction
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