Path Definitions

reversible retrogressive state in which cells/tissues adjust to sublethal conditions and demonstrate corresponding (graded) losses of function, altered metabolism, and morphological changes

abnormal accumulation of intracellular water within cells and tissues

more severe morphological form of acute cellular swelling; most common in epithelium; CPE of viral infections

lipid accumulation in non-adipose tissue

accumulation of mucin-like material resembling/equivalent to embryonic CT (proteinic vs polysaccharide/mucus-like)

pinocytosis (cellular phagocytosis) of extracellular proteins and/or denaturation of cytoplasmic proteins (coagulation of proteins)

from of hyaline degeneration; coagulation of myofibrils in skeletal muscle (densely eosinophilic amorphous material in sarcoplasm)

spontaneous disintegration of tissues following somatic death (mediated by endogenous lytic enzymes and bacterial proteolytic processes) **postmortem

programmed cell death (ordered disassembly of cell from within) that occurs in a viable host

abnormal (accidental) death of cells/tissues in a viable host

all tissues start out as coagulation necroses and proceed from that point; some chance of replacing with normal tissue

form of coagulation necrosis restricted to skeletal or cardiac muscle

form of coagulation necrosis caused by sudden-onset loss of blood vascular supply (ischemia)

characterized by loss of both tissue architecture and individual cellular detail; accompanied by prominent inflammatory responses and mineralization; virtually no chance of replacing with normal tissue

characterized by rapid disintigration of necrotic tissue into liquid mass

death of focal areas of adipose tissues leading to release of constituent portions of fat

group of diseases characterized by extracellular deposition of proteinic material in tissues

deposition of insoluble minerals (usually calcium salts) during life

normal developmental or metaplastic tissue change where true bone is formed in tissue and mineralized

deposition of crystals of uric acid and urates (products of protein metabolism) in tissues

excessive accumulation of hemosiderin-laden macrophages; tissues turn golden-brown; deposits stain positively for iron (Prussian blue)

clinical condition results in abnormal accumulation of pigment associated with hemoglobin catabolism; bilirubin - yellow, cholebilirubin - greenish yellow

excess hemoglobin breakdown; increased unconjugated water-insoluble hemobilirubin in serum

due to blockage of excretion of bile; increased conjugation of soluble cholebilirubin in serum

• reduction in oxygen-carrying capacity of blood due to reduction in number of circulating erythrocytes, hemoglobin/iron, or both
• **generalized disturbance of oxygen transport

• hypovolemia (decreased blood volume) resulting from rapid onset imbalance between blood volume (decreased cardiac output) and vascular bed volume (increased peripheral resistance)
• **generalized disturbance of oxygen transport

• systemic decrease in water content
• **disturbance of fluid balance

• accumulation of abnormal quantities of water (transudate) in interstitial tissues/body cavities
• **disturbance of fluid balance

intracellular water accumulation in brain

extracellular water accumulation due to congenital or acquired obstruction of flow

• excess blood volume (contained within vessels) on arterial side of capillary bed
• **intravascular fluid imbalance

• accumulation of excess blood on venous side of capillary bed (due to decreased outflow)
• **intravascular fluid imbalance

• premortem escape of whole blood from any part of blood vascular system
• **blood volume loss

• inappropriate coagulation of blood constituents within the circulatory system during life; must be attached to vessel walls
• **vascular obstruction

• intravascular foreign (usually particulate) matter mechanically transported by the vascular system and lodges at a site distant to its point of origin
• **vascular obstruction

• localized area of ischemic coagulation necrosis produced by rapid mechanical blockage of arterial blood supply accomblished by obstruction within or compression without
• **vascular obstruction

• rapid onset systemic condition characterized by uncontrolled activation of intrinsic coagulation systems with development of intravascular fibrin thrombi and emboli - systemic capillary thrombosis
• **vascular obstruction