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Marfan's Syndrome
fibrillin mutated, CT disorder
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deep wrinkled of photoaged skin
remodelin fibrillin microfibrils by chronic sun exposure
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Proteoglycans
- in ground substance
- core protein wiht associated GAG's
- hyaluric acid- viscous stuff in joint (backbone in addrecan fyi)
- But hi glycoprotein amt = highe proteins
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Macrophages
- Histiocyted- fixed
- Kupffer cells- in sinusoids
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Plasma cell
- absent of large granules
- heterochromatic, cartwheel
- basophilic cytoplasm, rER
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Eosinophil
allergic reactions, parasitic infection, chronic inflammation
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Mast cells
- densely staing granules
- release histamin, heparin, serotonin
- IgE receptor expressed
- long lived
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Fibroblast
- turn into myofibroblast to remodel/construct CT
- link epithelial cell with ECM through integrin
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