Immunology

• Study of the immune system
• Biological basis for protection against infection
• Mediated by cells and proteins
• Latin term, immunis, meaning exempt
• Edward Jenner

Deliberate induction of an immune response to a pathogen by introducing a dead or non-pathogenic form of the pathogen.

Non-pathogenic

HepB

• From birth
• Relatively non-specific
• Fast, early part of response
• No memory
• Granulocytes

• Changes over time
• Specific
• Develops slowly
• Memory
• Lymphocytes

• 
• Phagocytosis
• Antigen presentation

• 
• Antigen uptake
• Antigen presentation

• 
• Phagocytosis

• 
• Parasites

• 
• ????????

Allergic Response

Virus killer

• Macrophage
• Dendritic cell
• Neutrophil
• Eosinophil
• Basophil
• Mast Cell
• NK cell

• Lymphocytes
• B-cells
• T-cells

• originate and mature in bone marrow
• secrete antibody
• CD19⁺

• Originate in bone marrow and mature in Thymus
• Become effector T cells
• CD4⁺ - cell surface protein, kills bacteria
• CD8⁺ - viral and tumor