Kinetics Quiz 2

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Volume of distribution after oral or IM administration

V = amount of drug administered/KxAUC
Peak plasma concentration following an oral dose occurs when

elimination = absorption
Short time to peak =

rapid absorption
Absorption rate

fraction of drug present at the absorption site that is absorbed per unit time
if Ka is greater than 1

in a time unit almost all drug would be absorbed over that time
High Ka indicates

rapid absorption
Ka equals

the negative slope of the residual line
MEC

minimal effective concentration
Onset is where

drug concentration levels reach the MEC
Offset is where

drug plasma levels fall below MEC
tmax is when

time of peak plasma concentration
MTC

Minimal toxic concentration
Ks

rate describing disintegration and dissolution of a solid dosage form
Proceses which control the rate of drug going into solution also control

the rate of absorption
generally Ks is _____ than Ka

much smaller
products which contain essentially identical amounts of the identical active ingredient in identical dosage forms, and which meet existing physicochemical standards

chemical equivalents
chemical equivalents which when administered in the same amounts will provide essentially the same bioavailability, as measured by blood levels or urinary excretions

biological equivalents
chemical equivalents which when administered in the same amounts will provide essentially the same therapeutic effect as measured by the control of a symptom or a disease

therapeutic equivalents
the ultimate criterion for assessing equivalence of drug products

therapeutic equivalents
F =

absolute bioavailability from the oral dosage form or the fraction of the dose which actually reaches the systemic circulation
Greatest factor which can affect the extent to which a number of drugs are absorbed

formulation

Author

Rx2013

62277

Card Set

Kinetics Quiz 2

Description

kinetics quiz 2

Updated

2011-01-27T03:04:36Z

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