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What anemias are Hypoproliferative/Hyperproliferative?
- Hypo: IDA, ACD (Underproduce RBC)
- Hyper: SA, H (Destroyed RBC)
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What is the diff b/t Insuff/Ineff erythro.?
- Insuff: underproduced RBC, low CR
- Ineff: RBC destroyed early, high IBIL
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What happens to transferrin in cases if iron deficiency/overload?
- Deficiency: Increase transferrin
- Overload: decrease transferrin
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What is the relation b/t ferritin, TIBC and transferrin levels?
Ferritin is inverse both TIBC & Transferrin
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How do you calculate your % saturation of Iron?
Serum Iron/TIBC = % iron saturation of transferrin
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How many mg of iron are there per milliliter?
0.5 mg/1ml
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What is the relation b/t iron and hepcidin?
work together, as one goes up the other follows
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What interleukins are involved in ACD?
IL-1/6
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What happens with the interleukins during hypoferremia?
- IL-1: releases lactoferrin from neutrophils to transfer extra iron to macrophages for degradation
- IL-6: increases hepcidin to not exocytose the iron in the macrophage
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What are the two types of sideroblastic anemia and their causes?
- 1) inherited: ALA-S2
- 2) Acquired: alcoholism, lead poisoning ***more common***
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What happens to hepcidin during hypoxia and why?
- Hepcidin decreases
- Occurs b/c there is a higher need for erythropoiesis
- This calls for more iron which needs more FPN
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How does TIBC and Ferritin compare in IDA and ACD?
- ACD: TIBC low, Ferritin high
- IDA: TIBC high, Ferritin low
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