Immuno, Innate Imm: Neut, MO

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Ways in which the innate immune sys responds (4):
- Inflammation
- Phagocytic Cells
- NK Cells
- Soluble Defense Factors
Functions of inflammation?

Activation and directed migration of cells (Neutrophils and macrophages
Phagocytic Cells include:
- Monocytes(tissue)/Macrophages(blood)
- Granulocytes (i.e. neutrophils)
Soluble Defense Factors include:
- Enzymes
- Defensins
- Interferons
- Complement Proteins
Functions of complement proteins (3):
- Cell Lysis
- Chemotaxis
- Opsonins
Cytokines-

Proteins that mediate cellular interactions and regulate cell growth and secretion.
Interferons-

Cytokines that interfere with viral replication (soluble defense factor)
Complement Proteins-

serum and cell surface proteins that can be activated by innate/acquired immune mech (soluble defense factor)
Defensins-

Bacterial Peptides for killing bacteria
Functions of Complement Proteins:
- Cell Lysis
- Chemotaxis
- Coat Microbes for phagocytosis (opsonins)
Elevated neutrophils-

Neutrophilia
Neutrophils reside in...
- Circulating Pool (CP)
- Marginal Pool (MP)
Neutrophil life span

6-10 hrs - a few days
Functions of Integrins (2):

Cell surface protein on neutrophil that binds it to the capillary endothelium
Two receptor types on antibody:
- Fab - binds antigen
- Fc - binds complement protein
Steps of phagocytosis
- Chemotaxis
- (adhesion and emigration)
- Adherence to microbe
- Ingestion
- Destruction
Chemokines-

Cytokines that attract specific cells and mediate inflammatory response (for phagocytosis)
Opsonins-

Proteins that promote binding of pathogens to phagocytes
Two ways in which Destruction is carried out:
- Oxygen DEP killing with phagosome
- Oxygen INDEP killing with phagoLYSOsome
Bacteria that can survive inside macrophages (5):
- Mycobacterium bovis
- Rhodococcus equi
- Brucella abortus
- Listeria monocytogenes
- Salmonella typhimurium
BW seen w/ Leukocyte Adhesion Deficiency
- Neutrophilia (+)
- Leukocytosis (+)
- Monocytosis (+)
BLAD P's present:
- Gingivitis
- Pneumonia
Eosinophil tasks:
- Phagocytosis (minor)
- Killing parasites (major)
Basophil Tasks:
- Inflammation
- Immune Response
- Allergic Response
Macrophage life span:

Long (w/ sustained phagocytosis)
Steroids and PG's down-regulate...

Macrophages
Macrophage Functions (4):
- Phagocytosis
- Secretion
- Wound Healing
- *Antigen Presenting
Cytokines secreted by macrophages (2):
- Monokines
- Interleukins
Interleukins-

Proteins that act as growth and differentiation factors for cells of the immune system
Interleukin TNF-a is produced by both ____ & ____

Macrophages and Mast Cells (inflammatory mediator)
Removal of...

Large Antigens:
Small Antigens:
- Large Antigens: Phagocyte -> Spleen
- Small Antigens: Soluble Immune complex -> Macrophage
PAMP-
- Recognizable molecules on microbes that are essential for the survival of the microbe
- (Pathogen-Associated Membrane Patterns)
PRR-
- Receptors on macrophages that recognize groups of pathogens
- (Pattern Recognition Receptors)
*TLR-
- Type of PRR (receptor on macrophages) that interacts with PAMP (molecule on microbes)
- (Toll-Like Receptor)
Interaction btw. PRR and PAMP=>
- Phagocytosis
- Activation of cytokines that induce inflammation
NK cells lack receptors for:
- FcR (Fc part of antibody)
- Complement Proteins
NK cells target cells that lack ___ and those that have ___ & ___
- ...lack MCH-I
- ...have FcR & IFN-a
- (IFN = interferon on virally infected cells)
NK cells kill by

Apoptosis

Author

HLW

62058

Card Set

Immuno, Innate Imm: Neut, MO

Description

Innate Imm

Updated

2011-01-26T20:50:54Z

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