Pharmacology

what is a drug that interferes with the action of an agonist?

t/f an antagonist has no effect in the absence of an agonist
True False

how can antagonists be classified?

what are the two types of receptor antagonists

what type of antagonist has affinity for a receptor but no efficacy (Can't cause an effect)

does a competitive antagonist form a reversible or irreversible drug receptor complex

the presence of a _______ antagonist reduces the potency of the agonist

what type of antagonist prevents receptor activation?

does a noncompetitive antagonist produce a reversible or irreversible drug receptor complex

the presence of a _____ antagonist reduces the efficacy of the agonist

what type of receptor antagonist reduces the potency of the agonist? the efficacy?

what two forms can a nonreceptor antagonist be?

a ______ antagonist may either bind a molecule at some point in the activation pathway or directly inhibit the agonist

a ____ antagonist activates pathways that oppose the action of the agonist

what have both agonistic and antagonistic properties?

when a mixed agonist-antagonist is used alone how will the drug behave?

when another drug is taken with a mixed agonist-antagonist and competes for the same receptor site how will it act?

what are the two was a receptor is classified?

how are receptors subclassified?

how many receptor types or subtypes are on a cell

t/f any drug at high enough concentration can produce a toxic effect (overdose)
True False

what refers to the undesirable effects associated with the administration of therapeutic dosages of drugs

what are the adverse effects of toxicity be? (2)

the dose of a drug required to produce a desired response in 50% of the individuals with in the same population is called?

if death is the measured end point how is the ED50 expressed?

what does a steep dose response curve indicate between minimal and maximal effects?

how is the margin of safety of a drug expressed?

what is the TI an actual ratio of?

the _____ the TI the safer the drug

two similar drugs A and B are being compared. The therapeutic index is computed for both of them the TI for drug A is 8.5 and the TI for drug B is 10. Which drug is relatively more safe?