today what is the practitioners responsibility for drugs?
clinical applications of the knowledge of the drugs
what are the four important principles an oral health professional needs to understand about pharmacology?
knowing how a drug works
oral health education info related to drug effects
risks of taking a drug
what is the mechanism of action?
knowing how a drug works
what is the science of molecular interactions between drugs and body constituents
what are the four steps to drug induced effect?
delivery of molecule to tissue cells
complex formation with receptor (site of action)
molecular event causing an effect
mechanism of action
t/f not all drugs interact with specific receptors to cause an effect
what are the 7 characteristics of drug receptors?
location on the cell surface or within the cell
hundreds of different recptors on a single cell
complementary fit between drug and receptor
hydrophilic or hydrophobic
only one drug molecule can occupy a receptor at one time
t/f a drug receptor can only be located on the outside of the cell not within.
false-cells surface and within
there must be a complimentary fit between the ____ and the _____
drug and receptor
t/f only one drug molecule can occupy a receptor at one time
what are the four chemical bonds
von der Waals forces
what are the most common types of bonds between drugs and receptors?
hydrogen and ionic bonds
which chemical bonds are weak and easily reversed?
t/f hydrogen bonds are generally stronger than ionic bonds
what is the strongest type of bond?
what is a dental example of a covalent bond?
tetracycline and dentin to produce a permanent intrinsic discoloration
what kind of chemical bond is described as contributing to mutual attraction between molecules
von der waals forces
drug molecules move in constant ______ motion, _____ then _____ the bond, then _____ again according to the ______ of the molecule and ______ from other drug molecules
binding then releasing
the most common type of chemical bond between a drug molecule and receptor is?
hydrogen and ionic binding
when a drug molecule moves so close to its receptor that the attractive force between them becomes great enough to overcome the random motion of a drug molecule, the drug binds to the receptor, what is the phenomenon?
the affinity of a drug for a particular receptor and the type of binding that occurs is related to the drugs what?
can two drugs occupy one receptor at one time?
nope! only one molecule can bind to a receptor at a time
t/f drugs with good affinity have greater potency
good affinity is directly related to what?
how is affinity expressed?
by dissociation constant and concentration
what is the dissociation constant of affinity?
the concentration of a drug required in solution to achieve 50% occupancy of its receptors
what are drugs that have direct stimulatory effects on receptors called?
a _____ agonist produces a significant physiologic response when only a relatively small number of receptors are occupid
the ability of an agonist to interact with a receptor and initiate a response is the function of what?
when a small dose of a drug (_____) produces a desired effect the drug has good _______ and good _____ _____
a ______ agonist must be bond to many more receptors to produce the same effect as a _____ agonist
a _____ agonist has lower affinity and or lower intrinsic activity than a ____ agonist
a ______ agonist has affinity for the receptor but very low intrinsic activity
what kind of agonist will never produce the same effect as other agonists even with all receptors occupied?
the _____ and the _____ ______ of an agonist determine efficacy of a drug
what is the maximum response produced by a drug
additional doses would produce no further beneficial effect, what is this concept?
as with affinity of a drug for a particular receptor the efficacy of a drug is also related to what?
its chemical structure
what is the lowest dose of a drug that will produce a measurable response called?
what is defined as the relative pharmacologic activity of a dose of a compound compared with a dose of a differenct agent producing the same effect
what is used to compare effect of two drugs
______ is related to the affinity of a drug to its receptor whereas ________ is related to the intrinsic activity of that drug once a drug receptor complex is formed
potency is related to the _______ of a drug to its receptor whereas efficacy is related to the ____ _____ of that drug once a drug receptor complex is formed
the term that describes the maximum response produced by a drug is?