1. today what is the practitioners responsibility for drugs?
    clinical applications of the knowledge of the drugs
  2. what are the four important principles an oral health professional needs to understand about pharmacology?
    • knowing how a drug works
    • potential ADEs
    • oral health education info related to drug effects
    • risks of taking a drug
  3. what is the mechanism of action?
    knowing how a drug works
  4. what is the science of molecular interactions between drugs and body constituents
  5. what are the four steps to drug induced effect?
    • delivery of molecule to tissue cells
    • complex formation with receptor (site of action)
    • molecular event causing an effect
    • mechanism of action
  6. t/f not all drugs interact with specific receptors to cause an effect
  7. what are the 7 characteristics of drug receptors?
    • cellular macromolecules
    • location on the cell surface or within the cell
    • hundreds of different recptors on a single cell
    • complementary fit between drug and receptor
    • electrochemical charge
    • hydrophilic or hydrophobic
    • only one drug molecule can occupy a receptor at one time
  8. t/f a drug receptor can only be located on the outside of the cell not within.
    false-cells surface and within
  9. there must be a complimentary fit between the ____ and the _____
    drug and receptor
  10. t/f only one drug molecule can occupy a receptor at one time
    true yo
  11. what are the four chemical bonds
    • ionic bonds
    • hydrogen bonds
    • covalent bonds
    • von der Waals forces
  12. what are the most common types of bonds between drugs and receptors?
    hydrogen and ionic bonds
  13. which chemical bonds are weak and easily reversed?
    ionic bonds
  14. t/f hydrogen bonds are generally stronger than ionic bonds
    FALSE! weaker
  15. what is the strongest type of bond?
    covalent bonds
  16. what is a dental example of a covalent bond?
    tetracycline and dentin to produce a permanent intrinsic discoloration
  17. what kind of chemical bond is described as contributing to mutual attraction between molecules
    von der waals forces
  18. drug molecules move in constant ______ motion, _____ then _____ the bond, then _____ again according to the ______ of the molecule and ______ from other drug molecules
    • random
    • binding then releasing
    • binding again
    • affinity
    • competition
  19. the most common type of chemical bond between a drug molecule and receptor is?
    hydrogen and ionic binding
  20. when a drug molecule moves so close to its receptor that the attractive force between them becomes great enough to overcome the random motion of a drug molecule, the drug binds to the receptor, what is the phenomenon?
  21. the affinity of a drug for a particular receptor and the type of binding that occurs is related to the drugs what?
    chemical structure
  22. can two drugs occupy one receptor at one time?
    nope! only one molecule can bind to a receptor at a time
  23. t/f drugs with good affinity have greater potency
  24. good affinity is directly related to what?
  25. how is affinity expressed?
    by dissociation constant and concentration
  26. what is the dissociation constant of affinity?
    the concentration of a drug required in solution to achieve 50% occupancy of its receptors
  27. what are drugs that have direct stimulatory effects on receptors called?
  28. a _____ agonist produces a significant physiologic response when only a relatively small number of receptors are occupid
  29. the ability of an agonist to interact with a receptor and initiate a response is the function of what?
    intrinsic activity
  30. when a small dose of a drug (_____) produces a desired effect the drug has good _______ and good _____ _____
    • agonist
    • affinity
    • intrinsic activity
  31. a ______ agonist must be bond to many more receptors to produce the same effect as a _____ agonist
    • weak
    • strong
  32. a _____ agonist has lower affinity and or lower intrinsic activity than a ____ agonist
    • weak
    • strong
  33. a ______ agonist has affinity for the receptor but very low intrinsic activity
  34. what kind of agonist will never produce the same effect as other agonists even with all receptors occupied?
  35. the _____ and the _____ ______ of an agonist determine efficacy of a drug
    • affinity
    • intrinsic activity
  36. what is the maximum response produced by a drug
  37. additional doses would produce no further beneficial effect, what is this concept?
    ceiling dose
  38. as with affinity of a drug for a particular receptor the efficacy of a drug is also related to what?
    its chemical structure
  39. what is the lowest dose of a drug that will produce a measurable response called?
    threshold dose
  40. what is defined as the relative pharmacologic activity of a dose of a compound compared with a dose of a differenct agent producing the same effect
  41. what is used to compare effect of two drugs
  42. ______ is related to the affinity of a drug to its receptor whereas ________ is related to the intrinsic activity of that drug once a drug receptor complex is formed
    • potency
    • efficacy
  43. potency is related to the _______ of a drug to its receptor whereas efficacy is related to the ____ _____ of that drug once a drug receptor complex is formed
    • affinity
    • intrinsic activity
  44. the term that describes the maximum response produced by a drug is?
Card Set
ch 2 part 1