Pharm, Pharmacokinetics

  1. Bioavailability-
    measure of the extent of drug absorption. (usually compares routes)
  2. Absorption-
    Passage of drugs across body and cell membranes in order to reach their site of action and the target receptors.
  3. 3 general mechanisms for drug passage:
    • Passive Diffusion
    • Carrier Mediated Transport
    • Pinocytosis
  4. Penn in the renal tubules is an example of ...
    carrier mediated transport
  5. Passive Diffusion-
    route for drug passage, either through aqueous pores or through the liprprotein region
  6. The brain and testis capillaries have an absence of...
    aqueous pores
  7. Two types of passive diffusion:
    • Aqueous
    • Lipid
  8. Conditions of Passive Diffusion
    Small Molecules...
    Large Molecules...
    • Small- penetration by filtration though pores
    • Large- Large pore, or unionized and lipid soluble
  9. Major Route for drug passage:
    Passive Diffusion
  10. Which type of carrier mediated transport involves the use of E
  11. What barriers exist to protect the brain?
    • Blood-CSF (choroid plexus)
    • Blood-Brain (cerebral cap)
    • Glial Cell Layer
  12. A high partition coefficient indicates...
    • ?short duration?
    • p17
  13. In general, it is the ____ drug that passes across the membrane
  14. Ion Trapping, in general, leads to...
    the accumulation of acids of the basic side of a membrane and vice versa
  15. Pseudodistribution Equilibrium-
    Peak isn't an actual equilibrium b/c elimination and absorption begins at the same time
  16. Biotransformation-
    processes to facilitate excretion and render drugs less potent
  17. Pro-drugs-
    Drugs that are inactive until metabolized
  18. 3 Examples of pro-drugs:
    • Protonsil -> sulfanilamide
    • Hetacillin -> ampicillin
    • Febantel -> fenbendazole
  19. phenylbutazone ->
  20. aspirin ->
    salicylic acid
  21. primidone ->
    • Phenobarbital
    • phenylethylmalonamide
  22. codein ->
    some morphine
  23. Drugs metabolized in the liver tend to be
    lipid soluble
  24. biotransformation yields products that are more ___ than their parent compounds
    polar (water soluble)
Card Set
Pharm, Pharmacokinetics