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Toxicology Exam 1

  1. NOAEL
    • No observed adverse effect level
    • highest dose from a study with no adverse effects
  2. LD50 for alcohol
    10,000 mg/kg
  3. LD 50 for NaCl
    4000 mg/kg
  4. LD50 for morphine
    900 mg/kg
  5. nicotine LD50
    1 mg/kg
  6. dioxin LD 50
    0.001 mg/kg
  7. Inhibition of drug metabolism
    • SKF 525A
    • Piperonyl Butoxide
  8. Induction of Drug metabolism
    • Phenobarbital
    • 3-Methylcholantherene
  9. Exceeding the body's ability to conjugate while taking acetaminophen will reslut in
    Ac* from acetaminophen binding to proteins resulting in cell death
  10. Adverse reaction that results from previous sensitization to a particular chemical or to one that is structurally similar
    chemical allergy
  11. Type I hypersensitivity
    anaphylactic
  12. Type II hypersensitivity
    • Cytolytic
    • complete destruction of tissue at the area introduced to the poison
  13. Type III hypersensitivity
    • Arthus
    • repeated injections in the same place
  14. Type IV hypersensitivity
    • delayed hypersensitivity
    • Poison ivy
  15. Accute toxicity
    single time up to 14 days
  16. Subacute toxicity
    1-30 days
  17. subchronic toxicity
    30 days to 3 months
  18. Chronic toxicity
    greater than 3 months
  19. Tests that are preformed on mice and rabits
    • acute lethality
    • skin and eye irritants
    • sensitization
  20. tests that are performed on cats and dogs
    • subacute
    • sub chronic
  21. tests performed on monkeys
    • chronic tests
    • other tests
Author
Rx2013
ID
61150
Card Set
Toxicology Exam 1
Description
General Principles of Toxicology Part II
Updated

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