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Functional Class
Narcotic agonist, analgesic
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Mechanism of Action
Potent, short acting, synthetic narcotic agonist analgesic. Analgesia and sedation. Inhibits ascending pain pathways in CNS, increases pain threshold, and alters pain perception.
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Indications
Pain management
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Contraindications
Myasthenia gravis, hypersensitivity to opiates, MAOI use
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Precautions
Increased ICP, severe respiratory disores, hypotension, bradydysrhythmias
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Side Effects
- Severe respiratory depression
- Bronchoconstriction
- Chest-wall rigidity
- Sedation
- Bradycardia
- Diaphoresis
- N/V
- Miosis
- Blurred vision
- Hypotension
- Cardiac arrest
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Interactions
Effects increased with other CNS depressants. MAOI use may cause hypotension
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Dose and Route
Adult: 25-50 mcg slow IVP or IM q 5 max 150 mcg
Pedi: 0.5 mcg/kg slow IVP q 5 mins max 1.5 mcg/kg
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Pharmacokinetics
- Absorption = immediate
- Duration = 30-60 hours
- Half-life = 1.5-6 hours
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