imm.txt

inborn, genetically control, non-specific biochemical and physical barriers

Evolutionary, developed or aquired, specific,

inflamatory response, complement system, interferons

antigen is introduced and an antibody is formed

vacination and antibody is formed

Antibody is given to person

temporary in duration (natural - maternal or artificial - RhIG)

immediate response - IgE with mast cells

skin rash, uriteria, hay fever, anaphylaxis, asthma

antigen-antibody reaction with cell death through complement lysis

HDN, transfusion rx, autoimmune disease, Myasthenia gravis

soluble antigen-antibody form immune complexes

drug related autoantibodies, serum sickness, tissue damage by anaphylatoxins, manifestations of LE

chronic or delayed antigen stimulates specific T-Cell mediated cellular damage

graft vs host disease, allograft rejection, poison ivy, TB

hpersensitivity

circulating antibody

spleen, lymph nodes, thymus, liver, BM, BALT, GALT

phagocytosis, complement actiation (alternative pathway), epithelial barriers, inflammatory reations, toll-like receptors

MHC

TNF

MHC includes genes of ___ System and genes that encode other proteins ____ some complement components and some heat shock proteins

the genes that encode the MHC molecules are located on the short arm of chromosome ___

name the 3 classes of the MHC molecule

____ molecules are found on almost all cells of the body

the MHC Class I molecules are defined by 3 major Class I genes

each person will express Class I HLA molecules. 2 HLA-A, 2 HLA-B, & 2 HLA-C. each loci have many alleles for each molecule

there are 3 MHC Class II gene loci

there are 10 forms of Class II HLA molecules

____ molecules are heterodimeric

expressed on monocytes, macrophage, dentritic cells, and B lymphs

___molecules come from proteins that have been phagoytosed and endocytosed by antigen presenting cells. they are termed exogenous antigens and include most bacteria, parasites, and viral particles released from other cells

____ molecules have 20 genes coded for proteins of the complement system and proinflammatory molecules such as TNF

CD markers

cortcal thymocytes, some APCs and B cells, strength of expression is inverse to expression of TCR/CD3

T lymphs

pan T marker, present in early thymocytes, NK cells, sheep cell rosette receptor activation and adhesion function (LFA-2)

developing and mature thymocytes and on 2/3 perpheral T cells, T helper cells and some macrophages, adhesion molecules that mediates MHC restriction, signal transmission, HIV receptor