-
inborn, genetically control, non-specific biochemical and physical barriers
INNATE
-
Evolutionary, developed or aquired, specific,
ADAPTIVE
-
inflamatory response, complement system, interferons
INNATE
-
antigen is introduced and an antibody is formed
ACTIVE ACQUIRED
-
vacination and antibody is formed
ACTIVE ACQUIRED
-
Antibody is given to person
PASSIVE ACQUIRED
-
temporary in duration (natural - maternal or artificial - RhIG)
PASSIVE ACQUIRED
-
immediate response - IgE with mast cells
TYPE I CELLULAR IMMUNITY
-
skin rash, uriteria, hay fever, anaphylaxis, asthma
TYPE I CELLULAR IMMUNITY
-
antigen-antibody reaction with cell death through complement lysis
TYPE II CELLULAR IMMUNITY
-
HDN, transfusion rx, autoimmune disease, Myasthenia gravis
TYPE II CELLULAR IMMUNITY
-
soluble antigen-antibody form immune complexes
TYPE III CELLULAR IMMUNITY
-
drug related autoantibodies, serum sickness, tissue damage by anaphylatoxins, manifestations of LE
TYPE III CELLULAR IMMUNITY
-
chronic or delayed antigen stimulates specific T-Cell mediated cellular damage
TYPE IV CELLULAR IMMUNITY
-
graft vs host disease, allograft rejection, poison ivy, TB
TYPE IV CELLULAR IMMUNITY
-
hpersensitivity
CELLULAR IMMUNITY
-
circulating antibody
HUMORAL IMMUNITY
-
spleen, lymph nodes, thymus, liver, BM, BALT, GALT
ORGANS OF THE IMMUNE SYSTEM
-
phagocytosis, complement actiation (alternative pathway), epithelial barriers, inflammatory reations, toll-like receptors
INNATE
-
MHC
MAJOR HISTOCOMPATIBILITY COMPLEX
-
TNF
TUMOR NECROSIS FACTOR
-
MHC includes genes of ___ System and genes that encode other proteins ____ some complement components and some heat shock proteins
MHC - TNF
-
the genes that encode the MHC molecules are located on the short arm of chromosome ___
6
-
name the 3 classes of the MHC molecule
MHC CLASS I
-
____ molecules are found on almost all cells of the body
MHC CLASS I
-
the MHC Class I molecules are defined by 3 major Class I genes
HLA-A. -B, -C
-
each person will express Class I HLA molecules. 2 HLA-A, 2 HLA-B, & 2 HLA-C. each loci have many alleles for each molecule
- HLA-A = 50
- HLA-B = 75
- HLA-C = 30
-
there are 3 MHC Class II gene loci
-
there are 10 forms of Class II HLA molecules
- HLA-DP = 2
- HLA-DQ = 4
- HLA-DR =4
-
____ molecules are heterodimeric
Class II
-
expressed on monocytes, macrophage, dentritic cells, and B lymphs
Class II HLA molecules
-
___molecules come from proteins that have been phagoytosed and endocytosed by antigen presenting cells. they are termed exogenous antigens and include most bacteria, parasites, and viral particles released from other cells
Class II HLA molecules
-
____ molecules have 20 genes coded for proteins of the complement system and proinflammatory molecules such as TNF
MHC Class III
-
CD markers
Clusters of Differentiation
-
cortcal thymocytes, some APCs and B cells, strength of expression is inverse to expression of TCR/CD3
CD1
-
-
pan T marker, present in early thymocytes, NK cells, sheep cell rosette receptor activation and adhesion function (LFA-2)
CD2
-
developing and mature thymocytes and on 2/3 perpheral T cells, T helper cells and some macrophages, adhesion molecules that mediates MHC restriction, signal transmission, HIV receptor
CD4
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