Infectious Disease- cephalosporine

  1. 1 st generation Cephalasoprin - Example and activity
    Cefazolin: MSSS staph and strep. Has many community acquired E-coli, Klebsiella, Proteus

    • - Skin and soft tissue infections
    • - Some surgical prophalaxis
  2. 2 nd generation Cephalosporins?
    - More active against Gram Negative less active against Gram positive some against gut anaerobes.

    example: Cefoxitin (GI and gyn prophylaxis), Cefotetan

    - H-Flu, Neisseria, and Gram positive.

    Used for PID, Abd surgery.
  3. 3 rd generation Cephalasporins? Example and activity

    Which three can cross the Blood brain Barrier ?

    Which has activity against Pseudomonas?
    N-Gonorrhea, H- influenzae, Enterobacteriacease (e-coli, klebsiella, proteus, Enterobacter and Serratia).

    Ceftriaxone, Cefotaxime, Ceftazidime (crosses blood brain)

    Pseudomonas activity: Ceftazidime
  4. 4th generation Cephalosporin

    Example? Activity?

    Same gram negative activity as 3rd generation and Gram positive coverage as 1st generation with limited anarobic coverage. Has activity against extended spectrum cephalosporin.
Card Set
Infectious Disease- cephalosporine
Antibiotics and ID