Infectious Disease- cephalosporine

Cefazolin: MSSS staph and strep. Has many community acquired E-coli, Klebsiella, Proteus

• - Skin and soft tissue infections
• - Some surgical prophalaxis

- More active against Gram Negative less active against Gram positive some against gut anaerobes.

example: Cefoxitin (GI and gyn prophylaxis), Cefotetan

- H-Flu, Neisseria, and Gram positive.

Used for PID, Abd surgery.

N-Gonorrhea, H- influenzae, Enterobacteriacease (e-coli, klebsiella, proteus, Enterobacter and Serratia).

Ceftriaxone, Cefotaxime, Ceftazidime (crosses blood brain)

Pseudomonas activity: Ceftazidime

Cefepine

Same gram negative activity as 3rd generation and Gram positive coverage as 1st generation with limited anarobic coverage. Has activity against extended spectrum cephalosporin.