Drugs Group 2

Platelet aggregation inhibitor

Keeps platelets from sticking together and preventingclot formation (prevents platelet aggregation)

Acute coronary syndrome

Active pathologic bleeding (GI, intracranial)

Bleeding (including GI, and intracranial)

300mg

Alkalinizing agent

When disassociated, bicarbonate binds with hydrogenion to decrease metabolic acidosis (mass action effect).When administered for TCA overdose, acts as adysrhythmic. Decreases the effects of hyperkalemia byshifting potassium into cells

Hyperkalemia, tricyclic antidepressant overdose. Late in themanagement of cardiac arrest, if at all

None

Patients must be breathing spontaneously or adequately ventilatedbefore receiving sodium bicarbonate

Few

Deactivates catecholamines, forms precipitate with calciumchloride (if sodium bicarbonate is given before or after any of thesedrugs, flush the IV line to prevent interactions)

1 milliequivalent/kg IV push

Antidiuretic Hormone

In high doses, vasopressin acts as a non-adrenergicperipheral vasoconstrictor. When given during CPR,vasopressin increases coronary perfusion pressure, vitalorgan blood flow, decreases defibrillation threshold

Ventricular fibrillation, pulseless ventricular tachycardia, PEA and/or asystole

None

Do not give in patients with perfusing rhythms

Single bolus dose of 40 units IV. After 3-5 min, if there is no clinicalresponse, epinephrine 1 mg every 3–5 min can be givenHow Supplied: 20units/ml vial

None in cardiac arrest