MED-Morphine

Narcotic analgesic

Naturally occurring opiate which acts on opiate receptors in the brain providing sedation and analgesia. Also has vasodilatory properties (caused by mast cell degranulation and histamine release) which increase peripheral venous capacity and decrease venous return to the heart. Reduces cardiac workload, myocardial oxygen demand and pulmonary venous congestion.

• CP associated with ACS
• Pulmonary edema, CHF
• Pain management

• Hypersensitivity
• Undiagnosed head injury
• Hypovolemia
• Severe hypotension
• Acute asthma
• COPD
• Respiratory depression

• Administer slowly and titrate to effect
• Undiagnosed abdominal injury

• Dizziness
• N/V
• Cramps
• Blurred vision
• AMS
• Constricted pupils
• Headache
• Seizures
• Drowsiness
• Bradycardia
• Respiratory depression
• Syncope
• Palpitations
• Hypotension
• Dry mouth

Enhanced CNS depression with antihistamines, sedatives, barbituates, alcohol. TCAs and MAOIs may precipitate hypotension

• Adult: 1-5 mg slow IV/IM q 5 mins up to 15 mg
• Pediatric: 0.1 mg/kg IV may repeat once after 10 mins

Titrate to pain and systolic >100 mmhg

• Onset: Immediate IV
• Duration: 2-7 hours IV

Naloxone can be used to reverse effects