Medchem Exam1

Renin-Angiotensin system participates in pathophysiology by
- Controlling Arterial blood pressure
- Renin converts Angiotensin to Angiotensin 1
- ACE Converts Angiotensin 1 to Angiotensin 2
Methods to decrease high blood pressure due to angiotensin II
- Inhibit ACE
- Block binding site on AT1 receptor => ARB
- AT1 receptor = GPCR
3 major effectos of angiotensin II
- Altered peripheral resistance (rapid)
- Altered renal function (slow)
- Altered cardiovascular structure
Drug Classes
- Ace Inhibitors
- Carboxyalkanoyl or mercaptoalkanoyl derivitives
- ARBs
4 Drug classes used to treat Myocardial Ischemia (angina pectoris)
- B-Adrenergic receptor antagonists
- Nitrovasodilators
- Ca²⁺Channel Antagonists
- Statins
Organic Nitrates
- Prodrug of Nitric Oxide
- Vasodilation
- Low Molecular mass: moderately volatile, oily liquid
- High Molecular mass: solid
Ca²⁺ Channel Antagonists
- Block contraction of muscle
- Bind to alpha-1 subunit of L-type Ca²⁺ Channel
Five classes of Ca2+ Antagonists
- Phenylalkylamines
- Benzothiazepines
- Dihydropyridines
- Diphenylpiperazines
- Diarylaminopropylamines
Statins
- Competitive inhibitor of HMG-CoA Reductace
- -Rate limiting step in cholesterol biosynthesis
- -OH in the 3 position
- Lactone insoluble, must convert to acid
Mechanism of action for MI drugs
- Improve balance of myocardial oxygen supply and demand
- -vasodilation
- -reduce cardiac work

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Medchem Exam1

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Cardiovascular agents

Updated

2010-02-03T01:15:07Z

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