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Medchem Exam1
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Renin-Angiotensin system participates in pathophysiology by
Controlling Arterial blood pressure
Renin converts Angiotensin to Angiotensin 1
ACE Converts Angiotensin 1 to Angiotensin 2
Methods to decrease high blood pressure due to angiotensin II
Inhibit ACE
Block binding site on AT1 receptor => ARB
AT1 receptor = GPCR
3 major effectos of angiotensin II
Altered peripheral resistance (rapid)
Altered renal function (slow)
Altered cardiovascular structure
Drug Classes
Ace Inhibitors
Carboxyalkanoyl or mercaptoalkanoyl derivitives
ARBs
4 Drug classes used to treat Myocardial Ischemia (angina pectoris)
B-Adrenergic receptor antagonists
Nitrovasodilators
Ca
2+
Channel Antagonists
Statins
Organic Nitrates
Prodrug of Nitric Oxide
Vasodilation
Low Molecular mass
: moderately volatile, oily liquid
High Molecular mass
: solid
Ca
2+
Channel Antagonists
Block contraction of muscle
Bind to alpha-1 subunit of L-type Ca
2+
Channel
Five classes of Ca2+ Antagonists
Phenylalkylamines
Benzothiazepines
Dihydropyridines
Diphenylpiperazines
Diarylaminopropylamines
Statins
Competitive inhibitor of HMG-CoA Reductace
-Rate limiting step in cholesterol biosynthesis
-OH in the 3 position
Lactone insoluble, must convert to acid
Mechanism of action for MI drugs
Improve balance of myocardial oxygen supply and demand
-vasodilation
-reduce cardiac work
Author
Anonymous
ID
5932
Card Set
Medchem Exam1
Description
Cardiovascular agents
Updated
2010-02-03T01:15:07Z
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