Pharm II (Immunosupression)1b

  1. WHat is Basiliximab?
    What is it used for?
    Basiliximab is a chimeric monoclonal antibody against CD-25 on T cells (IL-2 receptor α chain).

    used for the prophylaxis of acute organ rejection
  2. What is Daclizumab?
    What is it used for?
    Daclizumab is a humanized monoclonal antibody against CD-25 on T cells (IL-2 receptor α chain)

    used for the prophylaxis of acute organ rejection
  3. What is Infliximab?
  4. Blocks TNF-α receptors and used in RA & Crohn’s disease
  5. What is Omalizumab?
  6. Anti-IgE MAb used to treat severe bronchial asthma (treatment of last resort)
  7. what is Trastuzumab?
  8. Anti HER-2 receptor and used in HER-2 positive breast cancer
  9. What is Rituximab?
  10. Anti CD-20 on B cells and used in Non-Hodgkin’s lymphoma
  11. what is BeVacizumab?
  12. Inhibits VEGF from binding its receptor on endothelial cells. Approved for first line treatment with metastatic colon cancer.
  13. Glucocorticoids.
    What is there Mech of action?

    when are they used?
    Both immunosuppressant and anti-inflammatory activity. Suppress the cell-mediated immunity by inhibiting genes that code for the cytokines--> decreased T cell proliferation.

    -suppress the humoral immunity, causing B cells to express lesser IL-2 receptors--> low Ab synthesis.

    -Used to prevent and treat transplant rejection, autoimmune diseases and allergic reactions by Muromonab
  14. name the Immunomodulating agents
    • 1.Aldesleukin
    • 2.BCG
    • 3.Interferons
  15. What is Aldesleukin

    When is it used?
    Recombinant interleukin-2 (IL-2) that promotes the production of cytotoxic T lymphocytes and activates NK cells.
  16. What is BCG?

    When is it used?
    Bacille Calmette-Guerin

    Immunostimulant in the prevention and treatment of superficial bladder cancer (a intravesicular theropy)
  17. Interferones

    • •Interferon-α-2a:
    • CML, malignant melanoma and hepatitis B and C

    • •Interferon-β-1b:
    • Multiple sclerosis
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Pharm II (Immunosupression)1b
Pharm II (Immunosupression)1b