-
Pheochromatomas 10% rule?
- 10% arise in association with MEN-2A or MEN-2B
- 10% are extra adrenal
- 10% of nonfimailial are bilateral
- 10% are malignant
- 10% arise in childhood
-
MEN-1
- 3 P's
- Pituitary; adenomas
- Parathyroid; hyperplasia, adenoma
- Pancreatic; hyperplasia, adenoma, carcinoma
- adrenal; cortical hyperplasia
- Gene is MEN1
-
MEN-2A
- parathyroid hyperplasia
- adrenal; pheochromocytoma
- Thrroid C-cell hyperplasia, medullary carcinoma
- Gene RET
-
MEN-2B
- phochromatoma, c cell hyperplasia, medullary carcinoma,
- extra adrenal; mucocutaneous ganglioneuromas
-
Differenc between men 2 A and B
- A; has parathyroid hyperplasia
- B: has mucocutaneous ganglioneuromas , marfinoid characteristics (long skeleton)
|
|
