-
Discuss the role of histamines in allergy. Then state two anti-histamine
- Triple response via H1 receptor
- Vasodilation, flare, wheal
- Loratidine
- Cetrizine
-
Discuss the cause, signs, and treatment of multiple sclerosis
- Cause: T-cell activation in brain; demylanation; destruction of BBB
- Signs: gondolinum enhancing lesions shown in MRI
- Treatment:
- Glatiramer: increases tolerance, increases supressor cells, reduces relapse
- Fingolimod: activates and ternalizes ___ receptor; decreases level of lymphocytes
- Interferon: prevent Tc activation; apoptosis; cytokine alterations
-
Discuss mechanism of action of Thalidomide. Side effects?
- What is it: immunosuppressant
- Inhibits B2 and B3 integrins
- -- Which inhibits leokocyte adhesion
- Inhibits TNF-a
- S/e: it has two isomers: S and R
- R is responsible for birth defects
-
Discuss mechanism of action of mycophenolate mofetil
- What is it: immunomodulator
- Inhibits inosine monophosphate dehydrogenase
- Inhibits guanine synthesis
- Used with calcineurin inhibitors
-
Discuss 3 kinds of biological response modifiers
- ImiquimodIncreases cytokines
- Increases immune cell activity
- Apoptosis
- Synthetics
- Isoprinosine: synthetic purine; enhances WBC proliferation; used in AIDS
- MicroorganismsBacillus of Calmette-Guerin
- Its an attenuated virus
- Bring local immune response against tumor
|
|
